Two-Trace Model for Spike-Timing-Dependent Synaptic Plasticity

DOI10.1162/NECO_A_00707MaRDI QIDQ5380219zbMATH OpenOpenAlexWikidataFDO

Authors Rodrigo Echeveste, Claudius Gros

Publication date 4 June 2019

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1410.0557

zbMATH Keywords

hippocampuspostsynaptic neuroncortexspiking neural networkstiming-dependent synaptic plasticity

Mathematics Subject Classification ID

Neural biology (92C20) Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: We present an effective model for timing-dependent synaptic plasticity (STDP) in terms of two interacting traces, corresponding to the fraction of activated NMDA receptors and the Ca2+ concentration in the dendritic spine of the postsynaptic neuron. This model intends to bridge the worlds of existing simplistic phenomenological rules and highly detailed models, constituting thus a practical tool for the study of the interplay between neural activity and synaptic plasticity in extended spiking neural networks. For isolated pairs of pre- and postsynaptic spikes the standard pairwise STDP rule is reproduced, with appropriate parameters determining the respective weights and time scales for the causal and the anti-causal contributions. The model contains otherwise only three free parameters which can be adjusted to reproduce triplet nonlinearities in both hippocampal culture and cortical slices. We also investigate the transition from time-dependent to rate-dependent plasticity occurring for both correlated and uncorrelated spike patterns.

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Cites work

• A Calcium-Based Simple Model of Multiple Spike Interactions in Spike-Timing-Dependent Plasticity
• Multispike Interactions in a Stochastic Model of Spike-Timing-Dependent Plasticity
• Relating STDP to BCM
• Self-organized stochastic tipping in slow-fast dynamical systems
• Spatiotemporal specificity of synaptic plasticity: cellular rules and mechanisms
• Synergies Between Intrinsic and Synaptic Plasticity Mechanisms

Cited in

(13)

• A calcium-influx-dependent plasticity model exhibiting multiple STDP curves
• Tracking fast and slow changes in synaptic weights from simultaneously observed pre- and postsynaptic spiking
• A Calcium-Based Simple Model of Multiple Spike Interactions in Spike-Timing-Dependent Plasticity
• A biophysical basis for the inter-spike interaction of spike-timing-dependent plasticity
• Multispike Interactions in a Stochastic Model of Spike-Timing-Dependent Plasticity
• Synaptic and Temporal Ensemble Interpretation of Spike-Timing-Dependent Plasticity
• Discrete states of synaptic strength in a stochastic model of spike-timing-dependent plasticity
• Phenomenological models of synaptic plasticity based on spike timing
• Mechanisms and significance of spike-timing dependent plasticity
• Spike-timing dependent synaptic plasticity: a phenomenological framework
• Biophysical model of synaptic plasticity dynamics
• Kinetic models of spike-timing dependent plasticity and their functional consequences in detecting correlations
• Converging evidence for a simplified biophysical model of synaptic plasticity

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