Two-phase modeling of fluid injection inside subcutaneous layer of skin

DOI10.1016/J.IJENGSCI.2023.103935MaRDI QIDQ6072190zbMATH OpenFDO

Authors Abdush Salam Pramanik, Bibaswan Dey, Timir Karmakar, Kalyan Saha

Publication date 12 October 2023

Published in International Journal of Engineering Science (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2201.11673

zbMATH Keywords

adipose cellsbiphasic mixture theorycomposite stream functionline of injectionsubcutaneous injectiontissue anisotropy

Mathematics Subject Classification ID

Perturbations in context of PDEs (35B20) Navier-Stokes equations for incompressible viscous fluids (76D05) Biomechanics (92C10) Physiological flow (92C35) Medical applications (general) (92C50)

Abstract: Being motivated by the delivery of drugs and vaccines through subcutaneous (SC) injection in human bodies, a theoretical investigation is performed using a two-dimensional mathematical model in the cartesian coordinate. In general, a large variety of biological tissues behave as deformable porous material with anisotropic hydraulic conductivity. Consequently, one can adopt the field equations of mixture theory to describe the behavior of the interstitial fluid and adipose cell present in the subcutaneous layer of skin. During the procedure, a medical person takes a big pinch of the skin of the injection application area between the thumb and index finger and holds. This process pulls the fatty tissue away from the muscle and makes the injection process easier. In this situation, the small aspect ratio (denoted as $delta$) of the subcutaneous layer (SCL) i.e., $delt{a}^{2}sim0.01$ would simplify the governing equation for tissue dynamics as it becomes a perturbation parameter. This study highlights the issue of the mechanical response of the adipose tissue in terms of the anisotropic hydraulic conductivity variation, the viscosity of the injected drug, the mean depth of subcutaneous tissue, etc. In particular, the computed stress fields can measure the intensity of pain to be experienced by a patient after this procedure. Also, this study discusses the biomechanical impact of the creation of one or more eddy structures (s) near the area of applying injection, which is due to high pressure developed there, increased tissue anisotropy, fluid viscosity, etc.

Recommendations

• Using poro-elasticity to model the large deformation of tissue during subcutaneous injection
• Isogeometric analysis of subcutaneous injection of monoclonal antibodies
• scientific article; zbMATH DE number 4077009
• Flow-induced deformation from pressurized cavities in absorbing porous tissues
• Mathematical description of soft tissue mechanics

Cites work

• A micromechanical model for the Young's modulus of adipose tissue
• A multiphase model describing vascular tumour growth
• A note on flow reversal in a wavy channel filled with anisotropic porous material
• A theoretical study on the elastic deformation of cellular phase and creation of necrosis due to the convection reaction process inside a spherical tumor
• A two-phase model of solid tumour growth
• Deformation and fluid flow due to a source in a poro-elastic layer
• Effect of anisotropic permeability on convective flow through a porous tube with viscous dissipation effect
• Effect of anisotropic permeability on Darcy's law
• Flow in a wavy-walled channel lined with a poroelastic layer
• Flow-induced deformation from pressurized cavities in absorbing porous tissues
• Fluid flow over a thin deformable porous layer
• Forced convection in horizontal porous channels with hydrodynamic anisotropy
• Green's function of the Brinkman equation in a 2D anisotropic case
• Homogenization of a generalization of Brinkman's equation for the flow of a fluid with pressure-dependent viscosity through a rigid porous solid
• scientific article; zbMATH DE number 5316598 (Why is no real title available?)
• scientific article; zbMATH DE number 108067 (Why is no real title available?)
• scientific article; zbMATH DE number 823893 (Why is no real title available?)
• scientific article; zbMATH DE number 3414014 (Why is no real title available?)
• Hydrodynamics and convection enhanced macromolecular fluid transport in soft biological tissues: application to solid tumor
• Mass transfer and species separation due to oscillatory flow in a Brinkman medium
• Mathematical models of subcutaneous injection of insulin analogues: a mini-review
• Mechanics of liquid mixtures
• Mixture model for thermo-chemo-mechanical processes in fluid-infused solids
• Modelling solid tumour growth using the theory of mixtures
• Nutrient transport through deformable cylindrical scaffold inside a bioreactor: an application to tissue engineering
• ON A HIERARCHY OF APPROXIMATE MODELS FOR FLOWS OF INCOMPRESSIBLE FLUIDS THROUGH POROUS SOLIDS
• On boundary conditions for a certain class of problems in mixture theory
• On laminar steady flow in sinusoidal channels
• On the permeability of fibre-reinforced porous materials
• Poiseuille flow in a fluid overlying a porous medium
• Shear induced redistribution of fluid within a uniformly swollen nonlinear elastic cylinder
• Some nonlinear diffusion problems within the context of the theory of interacting continua
• The influence of growth-induced stress from the surrounding medium on the development of multicell spheroids

Cited in

(1)

• A two-phase model of early atherosclerotic plaque development with LDL toxicity effects

This page was built for publication: Two-phase modeling of fluid injection inside subcutaneous layer of skin

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6072190)