twoCoprimary
Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.
- Exact power and sample size in clinical trials with two co-primary binary endpoints
- Sample size calculation in clinical trials with two co‐primary endpoints including overdispersed count and continuous outcomes
- Sample size determination in clinical trials with multiple co-primary endpoints including mixed continuous and binary variables
- Sample size determination in clinical trials with multiple co‐primary binary endpoints
- Sample Size Determination in Superiority Clinical Trials with Multiple Co-Primary Correlated Endpoints
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