Universal optimality of Patterson's crossover designs

DOI10.1214/009053605000000723MaRDI QIDQ817998zbMATH OpenOpenAlexFDO

Authors Kirti R. Shah, Mausumi Bose, D. Raghavarao

Publication date 23 March 2006

Published in The Annals of Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0603083

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05) Statistical block designs (62K10)

Abstract: We show that the balanced crossover designs given by Patterson [Biometrika 39 (1952) 32--48] are (a) universally optimal (UO) for the joint estimation of direct and residual effects when the competing class is the class of connected binary designs and (b) UO for the estimation of direct (residual) effects when the competing class of designs is the class of connected designs (which includes the connected binary designs) in which no treatment is given to the same subject in consecutive periods. In both results, the formulation of UO is as given by Shah and Sinha [Unpublished manuscript (2002)]. Further, we introduce a functional of practical interest, involving both direct and residual effects, and establish (c) optimality of Patterson's designs with respect to this functional when the class of competing designs is as in (b) above.

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