WSPsignal

MaRDI QIDQ7375362CRANFDO

Authors Julia Dyck, Odile Sauzet

Last update 9 July 2026

Copyright license MIT license, File License

Software version identifier 1.0.0

Description

Implementation of Bayesian and frequentist Weibull Shape Parameter (WSP) tests for signal detection in pharmacovigilance based on right-censored time-to-event data to flag associations between drugs and adverse events. The WSP test is based on the assumption of constant hazard reflected by a Weibull type distribution with shape parameters equal to one. Based on the shape parameter estimates (posterior distribution or point estimate), the WSP test method performs a hypothesis test on each shape parameter and combines them to a decision on the presence of a signal. Methods described in Sauzet and Cornelius (2022) <doi:10.3389/fphar.2022.889088>, Sauzet et al. (2024) <doi:10.1007/s40264-024-01460-2>, and Dyck and Sauzet (2025) <doi:10.48550/arXiv.2412.05463>.

Cites work

• Generalised weibull model-based approaches to detect non-constant hazard to signal adverse drug reactions in longitudinal data
• Optimal Significance Levels and Sample Sizes for Signal Detection Methods Based on Non-constant Hazards

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