DRviaSPCN (Q113676): Difference between revisions
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| Property / last update: 3 March 2022 / rank | |||||||||||||||
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publication date: 9 December 2021
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publication date: 28 February 2022
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publication date: 25 September 2023
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publication date: 13 January 2024
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13 January 2024
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A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results. | |||||||||||||||
| Property / description: A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results. / rank | |||||||||||||||
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| Property / author: Junwei Han / rank | |||||||||||||||
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| Property / author: Jiashuo Wu / rank | |||||||||||||||
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| Property / copyright license: GNU General Public License, version 2.0 / rank | |||||||||||||||
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edition/version: expanded from: GPL (≥ 2) (English) | |||||||||||||||
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software version identifier: ≥ 3.6 | |||||||||||||||
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Latest revision as of 18:55, 12 March 2024
Drug Repurposing in Cancer via a Subpathway Crosstalk Network
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | DRviaSPCN |
Drug Repurposing in Cancer via a Subpathway Crosstalk Network |
Statements
13 January 2024
0 references
A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
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expanded from: GPL (≥ 2) (English)
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