Exploring the interplay between virology and molecular crystallography (Q1001533): Difference between revisions

Summary: Polyhedra with icosahedral symmetry and vertices labelled by rational indices of points of a six-dimensional lattice left invariant by the icosahedral group allow a morphological characterization of icosahedral viruses which includes the Caspar-Klug classification as a special case. Scaling transformations relating the indexed polyhedron enclosing the surface with the one delimiting the central cavity lead to models of viral capsids observed in nature. Similar scaling relations can be obtained from projected images in three dimensions of higher-dimensional crystallographic point groups having the icosahedral group as a subgroup. This crystallographic approach can be extended to axial-symmetric clusters of coat proteins around icosahedral axes of the capsid. One then gets enclosing forms with vertices at points of lattices left invariant by the corresponding point group and having additional crystallographic properties also observed in natural crystals, but not explained by the known crystallographic laws.