Global properties for virus dynamics model with mitotic transmission and intracellular delay (Q542870): Difference between revisions

The author studies the following basic model of viral infections with mitotic transmission and intracellular delay \[ \begin{cases} \dot x(t)&=\lambda+rx(1-\frac{x+y}{K})-\mu x-\beta xv,\\ \dot y(t)&=\beta x(t-\tau)v(t-\tau)+ry(1-\frac{x+y}{K})-\alpha y,\\ \dot v(t)&=\alpha \eta y-\gamma v, \end{cases}\tag{1} \] where \(x(t), y(t)\) and \(v(t)\) represent the concentration of uninfected cells, infected cells and free virus, respectively. Here, uninfected cells are generated at a constant rate \(\lambda\) and die at rate \(\mu\) per uninfected cell. These cells are infected at rate \(\beta\) per uninfected cell per virion. \(\tau\) denotes the lag between the time of the virus contacts the uninfected cell and the time of the cell becomes actively infected. The mitotic proliferation of uninfected cells is described by \(rx(1-(x+y)/K)\) and mitotic transmission occurs at a rate \(ry(1-(x+y)/K)\), that is the mitotic division of actively infected cells. Uninfected cells and actively infected cells grow at the same rate \(r\) and \(K\) is the maximal number that total cell population proliferate. Each actively infected cell is assumed to produce \(\eta\) virus particles during its life time, and \(\gamma\) is the clearance rate of virus particles. The basic reproduction ratio is derived. By means of Lyapunov functionals, it is shown that if the basic reproduction ratio is less than unity, the infection-free equilibrium is globally asymptotically stable, and sufficient conditions are derived for the global stability of a chronic-infection equilibrium of system (1).