Model:6675376

Community: MathModDB

deterministic model

mathematical model

nonlinear model

static model

Available identifiers

MaRDI QIDQ6675376

uni uni reaction Michaelis Menten model without product and uncompetitive complete Inhibition via the steady state assumption, named after Leonor Michaelis, Maud Menten

List of contained entities

Michaelis Menten equation (uni uni reaction without product and uncompetitive complete inhibition - steady state assumption)	$v_0=\frac{V_{max,f}{c}_S}{K_S+(1+\frac{c_I}{K_{iu}})c_S}$
	$K_S$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{iu}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{max,f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_I$ represents inhibitor concentration
	$c_S$ represents substrate concentration
	$v_0$ represents initial reaction rate
enzyme conservation	$c_{E_0}=c_E+c_{EX}$
	$c_{EX}$ represents complexed enzyme concentration
	$c_{E_0}$ represents enzyme concentration
	$c_E$ represents enzyme concentration
initial inhibitor concentration (uni uni reaction)	$c_I(t=0)=c_{I_0}$	initial condition
	$c_I$ represents inhibitor concentration
	$t$ represents time
initial product concentration (uni uni reaction without product)	$c_P(t=0)=0$	initial condition
	$c_P$ represents product concentration
	$t$ represents time
initial substrate concentration (uni uni reaction)	$c_S(t=0)=c_{S_0}$	initial condition
	$c_S$ represents substrate concentration
	$t$ represents time
law of mass action	$v=k\prod _{i=1}^n{c}_i$
	$c_i$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate
mass balance	${\delta }_t+\mathrm{\nabla }F=0$
uni uni reaction (Michaelis Menten model without product - steady state assumption)

List of computational tasks

nonlinear parameter estimation (uni uni reaction without product and uncompetitive complete inhibition - Michaelis Menten model - steady state assumption)

List of assumptions

steady state assumption

Described at:

Enzyme Kinetics

(review)

Linearized by the following models

uni uni reaction uncompetitive complete inhibition (Dixon model without product - steady state assumption)

uni uni reaction uncompetitive complete inhibition (Eadie Hofstee model without product - steady state assumption)

uni uni reaction uncompetitive complete inhibition (Hanes Woolf model without product - steady state assumption)

uni uni reaction uncompetitive complete inhibition (Lineweaver Burk model without product - steady state assumption)

Further items linking to uni uni reaction uncompetitive complete inhibition (Michaelis Menten model without product - steady state assumption)

Item	Property
initial reaction rate of uni uni reaction without product and uncompetitive complete inhibition	modelled by
uni uni reaction (ODE model)	specialized by
uni uni reaction mixed complete inhibition (Michaelis Menten model without product - steady state assumption)	contains
uni uni reaction non-competitive complete inhibition (Michaelis Menten model without product - steady state assumption)	contains

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