Kinetics of cell-mediated cytotoxicity: Stochastic and deterministic multistage models (Q1061642): Difference between revisions
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Latest revision as of 18:32, 14 June 2024
scientific article
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English | Kinetics of cell-mediated cytotoxicity: Stochastic and deterministic multistage models |
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Kinetics of cell-mediated cytotoxicity: Stochastic and deterministic multistage models (English)
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1984
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The authors present two approaches to model the reaction between T- lymphocytes and abnormal cells. The first approach is a specialized application of queuing theory. The lymphocytes are the serving units, the target cells are the customers. The lysis of these cells occurs some random time after n lethal hits, delivered by n lymphocytes \((L_ n T\)- conjugates), \(1\leq n\leq 4\), or - another assumption - after forming an L \(T_ n\)-conjugate with \(1\leq n\leq 3\) target cells. The master equations are solved with different initial distributions and were compared with experimental findings. The second approach was a system of linear differential equations for the expected number of cells and conjugates in the different states. The authors define some conditions which guarantee the identity of both approaches.
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kinetics of cell-mediated cytotoxicity
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multistage models
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deterministic models
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immune response
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stochastic model
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T-lymphocytes
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queuing theory
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master equations
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