An unbiased test for the bioequivalence problem (Q1383083): Difference between revisions

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Property / DOI: 10.1214/aos/1030741076 / rank
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Property / reviewed by: Masafumi Akahira / rank
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Property / reviewed by: Masafumi Akahira / rank
 
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Property / full work available at URL: https://doi.org/10.1214/aos/1030741076 / rank
 
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Latest revision as of 19:10, 10 December 2024

scientific article
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English
An unbiased test for the bioequivalence problem
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    An unbiased test for the bioequivalence problem (English)
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    25 May 1998
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    The authors treat the problem demonstrating bioequivalence of treatments. The standard two one-sided tests procedure for bioequivalence is biased, so they construct an unbiased \(\alpha\)-level test. Since, in the construction, the rejection region of the unbiased test contains that of the two one-sided tests procedure, it is seen that the unbiased test is uniformly more powerful than the \(\alpha\)-level two-sided test procedure. The construction is numerically complemented and also the critical region is illustrated.
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    uniformly most powerful
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    pharmacokinetic parameters
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    two one-sided tests procedure
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    unbiased \(\alpha\)-level test
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