Using sacrificial cell spheroids for the bioprinting of perfusable 3D tissue and organ constructs: a computational study (Q2003682): Difference between revisions
From MaRDI portal
Created claim: Wikidata QID (P12): Q64938295, #quickstatements; #temporary_batch_1708298810402 |
ReferenceBot (talk | contribs) Changed an Item |
||
(3 intermediate revisions by 3 users not shown) | |||
Property / describes a project that uses | |||
Property / describes a project that uses: VMD / rank | |||
Normal rank | |||
Property / MaRDI profile type | |||
Property / MaRDI profile type: MaRDI publication profile / rank | |||
Normal rank | |||
Property / full work available at URL | |||
Property / full work available at URL: https://doi.org/10.1155/2019/7853586 / rank | |||
Normal rank | |||
Property / OpenAlex ID | |||
Property / OpenAlex ID: W2946546372 / rank | |||
Normal rank | |||
Property / cites work | |||
Property / cites work: Viscoelastic modeling of the fusion of multicellular tumor spheroids in growth phase / rank | |||
Normal rank | |||
Property / cites work | |||
Property / cites work: Modeling fusion of cellular aggregates in biofabrication using phase field theories / rank | |||
Normal rank |
Latest revision as of 20:35, 19 July 2024
scientific article
Language | Label | Description | Also known as |
---|---|---|---|
English | Using sacrificial cell spheroids for the bioprinting of perfusable 3D tissue and organ constructs: a computational study |
scientific article |
Statements
Using sacrificial cell spheroids for the bioprinting of perfusable 3D tissue and organ constructs: a computational study (English)
0 references
9 July 2019
0 references
Summary: A long-standing problem in tissue engineering is the biofabrication of perfusable tissue constructs that can be readily connected to the patient's vasculature. It was partially solved by three-dimensional (3D) printing of sacrificial material (e.g., hydrogel) strands: upon incorporation in another cell-laden hydrogel, the strands were removed, leaving behind perfusable channels. Their complexity, however, did not match that of the native vasculature. Here, we propose to use multicellular spheroids as a sacrificial material and investigate their potential benefits in the context of 3D bioprinting of cell aggregates and/or cell-laden hydrogels. Our study is based on computer simulations of postprinting cellular rearrangements. The computational model of the biological system is built on a cubic lattice, whereas its evolution is simulated using the Metropolis Monte Carlo algorithm. The simulations describe structural changes in three types of tissue constructs: a tube made of a single cell type, a tube made of two cell types, and a cell-laden hydrogel slab that incorporates a branching tube. In all three constructs, the lumen is obtained after the elimination of the sacrificial cell population. Our study suggests that sacrificial cell spheroids (sacrospheres) enable one to print tissue constructs outfitted with a finer and more complex network of channels than the ones obtained so far. Moreover, cellular interactions might give rise to a tissue microarchitecture that lies beyond the bioprinter's resolution. Although more expensive than inert materials, sacrificial cells have the potential to bring further progress towards the biofabrication of fully vascularized tissue substitutes.
0 references
sacrificial cell spheroids
0 references
bioprinting
0 references
perfusable 3D tissue
0 references
organ constructs
0 references