Exact analysis of a paired sibling data (Q1775981): Difference between revisions
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| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Exact analysis of a paired sibling data |
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Exact analysis of a paired sibling data (English)
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20 May 2005
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The authors discuss the problem of statistical analysis of genetic study of sibling pair data of \textit{F. C. Fraser} and \textit{A. D. Hunter} [Etiologic relations among categories of congenital heart malformations. The American Journal of Cardiology 36, 793--796 (1975)]. The data is in the form of a triangular table with vanishing diagonal entries, so the problem of fitting parametric models to such tables is investigated using Monte-Carlo methods. Exact \(p\)-values are computed for a test of parameter significance and a test of goodness-of-fit which contradict the model of quasi-independence and confirm the previous analysis by \textit{B. MacGibbon} [A log-linear model of a paired sibling study. In Proceedings of Statistics'81 Canada Conference, Eds. Y. Chaubey, T. D. Dwivedi, 193-197 (1983)].
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categorical data
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genetic data
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exact conditional test
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exponential family
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Monte-Carlo methods
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quasi-independence
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structural zeros
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sibling pair data
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fitting
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