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Simulating the sequential multi-arm multi-stage or platform trial with Bayesian approach using the 'rstan' package, which provides the R interface for the Stan. This package supports fixed ratio and Bayesian adaptive randomization approaches for randomization. Additionally, it allows for the study of time trend problems in platform trials. There are demos available for a multi-arm multi-stage trial with two different null scenarios, as well as for Bayesian trial cutoff screening. The Bayesian adaptive randomisation approaches are described in: Trippa et al. (2012) <doi:10.1200/JCO.2011.39.8420> and Wathen et al. (2017) <doi:10.1177/1740774517692302>. The randomisation algorithm is described in: Zhao W <doi:10.1016/j.cct.2015.06.008>. The analysis methods of time trend effect in platform trial are described in: Saville et al. (2022) <doi:10.1177/17407745221112013> and Bofill Roig et al. (2022) <doi:10.1186/s12874-022-01683-w>.
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Latest revision as of 18:55, 12 March 2024

Simulate and Analyse Bayesian Platform Trial with Time Trend
Language Label Description Also known as
English
BayesianPlatformDesignTimeTrend
Simulate and Analyse Bayesian Platform Trial with Time Trend

    Statements

    1.0.0
    15 March 2023
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    1.1.0
    5 May 2023
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    1.0.1
    2 May 2023
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    1.1.1
    12 June 2023
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    1.1.2
    25 June 2023
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    1.1.3
    22 August 2023
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    1.2.0
    5 October 2023
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    1.2.1
    11 October 2023
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    1.2.2
    22 November 2023
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    1.2.3
    7 December 2023
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    7 December 2023
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    Simulating the sequential multi-arm multi-stage or platform trial with Bayesian approach using the 'rstan' package, which provides the R interface for the Stan. This package supports fixed ratio and Bayesian adaptive randomization approaches for randomization. Additionally, it allows for the study of time trend problems in platform trials. There are demos available for a multi-arm multi-stage trial with two different null scenarios, as well as for Bayesian trial cutoff screening. The Bayesian adaptive randomisation approaches are described in: Trippa et al. (2012) <doi:10.1200/JCO.2011.39.8420> and Wathen et al. (2017) <doi:10.1177/1740774517692302>. The randomisation algorithm is described in: Zhao W <doi:10.1016/j.cct.2015.06.008>. The analysis methods of time trend effect in platform trial are described in: Saville et al. (2022) <doi:10.1177/17407745221112013> and Bofill Roig et al. (2022) <doi:10.1186/s12874-022-01683-w>.
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