A Newton-based approach for attributing tumor lethality in animal carcinogenicity studies. (Q5958580): Difference between revisions
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Revision as of 23:02, 28 February 2024
scientific article; zbMATH DE number 1715592
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English | A Newton-based approach for attributing tumor lethality in animal carcinogenicity studies. |
scientific article; zbMATH DE number 1715592 |
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A Newton-based approach for attributing tumor lethality in animal carcinogenicity studies. (English)
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3 March 2002
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A new Newton-based approach is proposed for finding the global maximum of a nonlinear function subject to various inequality constraints. This method can be applied to nonparametric maximum likelihood estimation problems to attribute tumor lethality in long-term carcinogenicity studies. This method is substantially faster and easier to implement than the Complex Method used by Ahn et al. (2000). This approach is very useful especially when there exist a large number of parameters of interest to be estimated and many nonlinear inequality constraints. A Monte Carlo simulation study is conducted to evaluate the computational efficiency and accuracy of the estimates obtained from the new approach. The advantages of using the Newton-based approach are illustrated with a real data set.
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Cause of death
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Inequality constraint
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Maximum likelihood
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Optimization
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Sacrifice
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