Global asymptotic stability of the size distribution in probabilistic models of the cell cycle (Q802489): Difference between revisions
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Latest revision as of 10:09, 30 July 2024
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English | Global asymptotic stability of the size distribution in probabilistic models of the cell cycle |
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Global asymptotic stability of the size distribution in probabilistic models of the cell cycle (English)
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1985
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Probabilistic models of the cell cycle maintain that cell generation time is a random variable given by some distribution function, and that the probability of cell division per unit time is a function only of cell age (and not, for instance, of cell size). Given the probability density, f(t), for time spent in the random compartment of the cell cycle, we derive a recursion relation for \(\psi_ n(x)\), the probability density for cell size at birth in a sample of cells in generation n. For the case of exponential growth of cells, the recursion relation has no steady-state solution. For the case of linear cell growth, we show that there exists a unique, globally asymptotically stable, steady-state birth size distribution, \(\psi_*(x)\). For the special case of the transition probability model, we display \(\psi_*(x)\) explicitly.
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global asymptotic stability
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generation time distribution
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cell cycle
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recursion relation
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exponential growth of cells
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linear cell growth
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size distribution
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transition probability model
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