On the analysis of oxygen diffusion and reaction in biological systems (Q1820082): Difference between revisions
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Revision as of 01:35, 20 March 2024
scientific article
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English | On the analysis of oxygen diffusion and reaction in biological systems |
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On the analysis of oxygen diffusion and reaction in biological systems (English)
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1987
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An analysis of oxygen diffusion and reaction in multiregion biological systems is presented. This analysis considers a time-dependent flux boundary condition and oxygen consumption governed by Michaelis-Menten kinetics. The mathematical problem is developed in a uniform fashion, so as to include both the single cell and anisotropic systems with distinct regions which are characteristic of either a multicell spheroid or a tumor mass. Both transient and steady-state solutions are obtained, based on orthogonal collocation. Literature results on single-cell analysis are corroborated, and detailed transient solutions are presented for the oxygenation of a multicell spheroid, and for systematic oxygenation of both small and large tumors.
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analysis of oxygen diffusion and reaction
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multiregion biological systems
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time-dependent flux boundary condition
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oxygen consumption
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Michaelis-Menten kinetics
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single cell
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anisotropic systems
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transient and steady-state solutions
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orthogonal collocation
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single-cell analysis
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oxygenation of a multicell spheroid
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tumors
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