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Latest revision as of 18:57, 25 June 2024

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Spectral clustering and its use in bioinformatics
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    Spectral clustering and its use in bioinformatics (English)
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    11 May 2007
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    The authors formulate a discrete optimization problem that gives a simple derivation of a widely used class of spectral clustering algorithms. These algorithms bundle objects into groups of similar objects, using the eigendecomposition of a matrix derived from the (real symmetric) matrix \(W=(w_{ij})\), where, for \(i\neq j\), \(w_{ij}\) is a measure of the similarity of the \(i\)th and \(j\)th objects, and \(w_{ii}=0\). The objects are regarded as vertices of an undirected graph. The authors' approach helps explain the difference observed between methods based on the normalized and unnormalized graph Laplacian. A numerical illustration is given using microarray datasets published by cancer researchers.
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    partitioning
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    scaling
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    balancing threshold
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    gene expression
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    Fiedler vector
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    graph Laplacian
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    random graph
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    numerical examples
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    discrete optimization problem
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    spectral clustering algorithms
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    eigendecomposition
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