A time delay model about AIDS-related cancer: equilibria, cycles and chaotic behavior (Q931042)

The paper is concerned with the dynamics of the HIV-1 infection in the presence AIDS-related cancer cells in tissue cultures. The model incorporates the time delay for the incubation phase during the HIV-1 infection and development of cancer and accounts for the dynamics of three cell populations: healthy cells, infected CD4+ T-lymphocytes, and cancer cells. The authors show that there exist up to six steady states and discuss their stability properties focusing attention on a cancer-HIV-healthy cells steady state. It turns out that longer incubation periods yield transition to AIDS under smaller reproduction rates of cancer cells. Conditions for the Hopf bifurcation leading to the birth of periodic solutions are established and chaotic behavior of solutions is discussed. As the bifurcation parameter increases, chaotic and periodic patterns in the behavior of solutions alternate. Numerical simulations using the dde23 routine of MATLAB are provided.