A model for the hepatic glucose metabolism based on Hill and step functions

DOI10.1016/j.cam.2015.01.036zbMath1326.92020OpenAlexW2046126037MaRDI QIDQ495110

Giuseppe Calamita, Marco Berardi, Marcello D'Abbicco, Luciano Lopez, Nicoletta Del Buono, Patrizia Gena

Publication date: 9 September 2015

Published in: Journal of Computational and Applied Mathematics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.cam.2015.01.036

zbMATH Keywords

step functionHill functionglucose-insulin modelmetabolic dysfunction

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Stability of solutions to ordinary differential equations (34D20) Systems biology, networks (92C42)

Related Items

A mixed MoL-TMoL for the numerical solution of the 2D Richards' equation in layered soils ⋮ Isochronous attainable manifolds for piecewise smooth dynamical systems ⋮ A note on attractivity for the intersection of two discontinuity manifolds

Cites Work

• Unnamed Item
• Qualitative simulation of genetic regulatory networks using piecewise-linear models
• A survey of numerical methods for IVPs of ODEs with discontinuous right-hand side
• Exact control of genetic networks in a qualitative framework: the bistable switch example
• Mathematical biology. Vol. 1: An introduction.
• A Filippov sliding vector field on an attracting co-dimension 2 discontinuity surface, and a limited loss-of-attractivity analysis
• Modeling the glucose-insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delays
• Piecewise-linear models of genetic regulatory networks: equilibria and their stability
• Sliding motion on discontinuity surfaces of high co-dimension. A construction for selecting a Filippov vector field
• Mathematical models and software tools for the glucose\,-\,insulin regulatory system and diabetes: an overview
• On the Equivalence between the Sigmoidal Approach and Utkin's Approach for Piecewise-Linear Models of Gene Regulatory Networks
• Enhanced modelling of the glucose–insulin system and its applications in insulin therapies
• A class of piecewise linear differential equations arising in biological models
• Modeling Impulsive Injections of Insulin: Towards Artificial Pancreas
• The Switching Threshold Reconstruction Problem for Piecewise-Affine Models of Genetic Regulatory Networks