Estimation and prediction of cell cycle specific effects of anticancer drugs

DOI10.1016/0025-5564(86)90044-1zbMath0607.92005OpenAlexW1967044220MaRDI QIDQ1086186

Frank Traganos, Marek Kimmel

Publication date: 1986

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(86)90044-1

zbMATH Keywords

compartment modelflow cytometryisotonic regressiontransition timecell cycle kinetic effects of anticancer drugschemotherapeutic treatment of cancercontinuous exposure kineticsdrug action curveestimation of distributions of cell residence timesexit curvesexponentially growing Friend erythroleukemia cellshigher drug concentrationslower drug concentrationsstathmokinetic experiments

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Physiological, cellular and medical topics (92Cxx)

Related Items (6)

Reduction of cytotoxicity to normal tissues by new regimens of cell-cycle phase-specific drugs ⋮ Evaluation of multitype mathematical models for CFSE-labeling experiment data ⋮ Reaction-diffusion approach to modeling of the spread of early tumors along linear or tubular structures ⋮ Stochastic Monotonicity and Continuity Properties of the Extinction Time of Bellman-Harris Branching Processes: An Application to Epidemic Modelling ⋮ Optimization of additive chemotherapy combinations for an in vitro cell cycle model with constant drug exposures ⋮ Mathematical model of tumor invasion along linear or tubular structures

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• Mathematical analysis of cancer chemotherapy
• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Exponential growth of a branching process usually implies stable age distribution

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