Mathematical model of cancer chemotherapy. Periodic schedules of phase- specific cytotoxic-agent administration increasing the selectivity of therapy

DOI10.1016/0025-5564(85)90073-2zbMath0565.92006OpenAlexW1990947948MaRDI QIDQ1059007

A. M. Zhabotinsky, Yu. A. Neyfakh, L. I. Churikova, M. P. Orlova, B. F. Dibrov

Publication date: 1985

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(85)90073-2

zbMATH Keywords

best interdosage perioddelayed noncentral gamma lawmean interdivision time of normal cellsoptimization of the protocols of cancer chemotherapeutic treatmentsoptimum scheduleuniform periodic control

Mathematics Subject Classification ID

Medical applications (general) (92C50) Population dynamics (general) (92D25) Numerical methods for mathematical programming, optimization and variational techniques (65K99)

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Cites Work

• Unnamed Item
• Mathematical models of the cell cycle with a view to tumor studies
• Optimal scheduling for cell synchronization by cycle-phase-specific blockers
• A method for the measurement of variability in cell lifetimes
• Design of optimal cancer chemotherapy using a continuous-time state model of cell kinetics
• Mathematical approaches to optimization of cancer chemotherapy
• Tumor growth and chemotherapy: Mathematical methods, computer simulations, and experimental foundations
• A FLOQUET THEORY FOR FUNCTIONAL DIFFERENTIAL EQUATION
• Simulation of cell-cycle kinetics based on a multicompartmental model

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