Design of optimal cancer chemotherapy using a continuous-time state model of cell kinetics

DOI10.1016/0025-5564(82)90024-4MaRDI QIDQ1165178zbMATH OpenOpenAlexFDO

Authors Kang G. Shin, Richard Pado

Publication date 1982

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(82)90024-4

zbMATH Keywords

bang-bang control policyChinese-hamster-ovary cell populationcontinuous-time state model of cell kineticsoptimal cancer chemotherapytumor-cell populationtwo-point boundary-value problem

Mathematics Subject Classification ID

Existence of optimal solutions belonging to restricted classes (Lipschitz controls, bang-bang controls, etc.) (49J30) Medical applications (general) (92C50)

Cites work

• A theoretical and computational method for determining optimal treatment schedules in fractionated radiation therapy
• Estimation of cell kinetic parameters from flow microfluorometry
• scientific article; zbMATH DE number 3306310 (Why is no real title available?)
• Natural Bilinear Control Processes
• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Optimal control of multiplicative control systems arising from cancer therapy
• Tumor growth and chemotherapy: Mathematical methods, computer simulations, and experimental foundations

Cited in

(5)

• Mathematical model of cancer chemotherapy. Periodic schedules of phase- specific cytotoxic-agent administration increasing the selectivity of therapy
• Singularity of optimal control in some problems related to optimal chemotherapy
• Scheduling the adjuvant endocrine therapy for early stage breast cancer
• Optimal control for a cancer chemotherapy problem with general growth and loss functions
• Role of optimal control theory in cancer chemotherapy

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