The dynamics of an optimally controlled tumor model: A case study
From MaRDI portal
Publication:1433148
DOI10.1016/S0895-7177(03)00133-XzbMath1043.92018MaRDI QIDQ1433148
L. G. de Pillis, A. E. Radunskaya
Publication date: 15 June 2004
Published in: Mathematical and Computer Modelling (Search for Journal in Brave)
optimal controlordinary differential equationscancermathematical modellingcompetition modelspopulation modelsimmune systemtumor
Applications of optimal control and differential games (49N90) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Dynamical systems in biology (37N25) Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60)
Related Items
Numerical simulations of wave propagation in a stochastic partial differential equation model for tumor-immune interactions ⋮ Multiple colonies of cancer involved in mutual suppression with the immune system ⋮ Modeling and analysis of nonlinear tumor‐immune interaction under chemotherapy and radiotherapy ⋮ The local and global dynamics model of a cancer tumor growth ⋮ Unnamed Item ⋮ A mixture-like model for tumor-immune system interactions ⋮ A model of tumor‐immune system interactions with healthy cells and immunotherapies ⋮ Stochastic dynamics of nonlinear tumor-immune system with chemotherapy ⋮ Studying the importance of regulatory T cells in chemoimmunotherapy mathematical modeling and proposing new approaches for developing a mathematical dynamic of cancer ⋮ Chaotic transitions in a tumor-Immune model under chemotherapy treatment ⋮ Unnamed Item ⋮ Nonautonomous Dynamical Systems in the Life Sciences ⋮ Bifurcation, multistability in the dynamics of tumor growth and electronic simulations by the use of Pspice ⋮ Optimal treatment strategies for delayed cancer-immune system with multiple therapeutic approach ⋮ An investigation on Michaelis-Menten kinetics based complex dynamics of tumor-immune interaction ⋮ Phase transitions in tumor growth. III: Vascular and metastasis behavior ⋮ Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer ⋮ Analysis of the dynamics of a tumor-immune system with chemotherapy and immunotherapy and quadratic optimal control ⋮ Optimal control strategy for cancer remission using combinatorial therapy: a mathematical model-based approach ⋮ AN ADAPTIVE PHARMACOKINETIC OPTIMAL CONTROL APPROACH IN CHEMOTHERAPY FOR HETEROGENEOUS TUMOR ⋮ Activation of effector immune cells promotes tumor stochastic extinction: a homotopy analysis approach ⋮ Personalized drug administration for cancer treatment using model reference adaptive control ⋮ Stochastic dynamics of Michaelis-Menten kinetics based tumor-immune interactions ⋮ Bifurcations and multistability in a virotherapy model with two time delays ⋮ Avoiding healthy cells extinction in a cancer model ⋮ Effects of the obesity on optimal control schedules of chemotherapy on a cancerous tumor ⋮ Mathematical and numerical analysis of a mathematical model of mixed immunotherapy and chemotherapy of cancer ⋮ Optimization of virotherapy for cancer ⋮ A deterministic and stochastic model for the system dynamics of tumor-immune responses to chemotherapy ⋮ The importance of chaotic attractors in modelling tumour growth ⋮ CHAOS IN A THREE-DIMENSIONAL CANCER MODEL ⋮ The influence of time delay in a chaotic cancer model ⋮ Optimal control problem for a general reaction-diffusion tumor-immune interaction system of mixed immunotherapy and chemotherapy ⋮ Control strategies for a tumor-immune system with impulsive drug delivery under a random environment ⋮ The effect of time ordering and concurrency in a mathematical model of chemoradiotherapy ⋮ Co-dimension two bifurcations analysis of a delayed tumor model with Allee effect ⋮ Dynamics of a Mathematical Model of Cancer and Immunoediting Scenarios Under the Variation of the Immune Cell Activation Rate ⋮ Implementation of fractional optimal control problems in real-world applications ⋮ Chaos and optimal control of equilibrium states of tumor system with drug ⋮ The chaos and optimal control of cancer model with complete unknown parameters ⋮ Stability analysis and fixed-time control of credit risk contagion ⋮ Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment ⋮ Adaptive backstepping controller design for MIMO cancer immunotherapy using Laguerre polynomials ⋮ Bifurcation and chaos analysis of tumor growth ⋮ Optimal control of effector-tumor-normal cells dynamics in presence of adoptive immunotherapy ⋮ An extended mathematical model of tumor growth and its interaction with the immune system, to be used for developing an optimized immunotherapy treatment protocol ⋮ A detailed study on a tumor model with delayed growth of pro-tumor macrophages ⋮ Chemotherapy and immunotherapy for tumors: a study of quadratic optimal control ⋮ Stability of Hahnfeldt angiogenesis models with time lags ⋮ Metaheuristics and Pontryagin's minimum principle for optimal therapeutic protocols in cancer immunotherapy: a case study and methods comparison ⋮ Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations ⋮ A cellular automata model of tumor-immune system interactions ⋮ Model for acid-mediated tumour invasion with chemotherapy intervention. II: Spatially heterogeneous populations ⋮ Optimal control for selected cancer chemotherapy ODE models: a view on the potential of optimal schedules and choice of objective function ⋮ Bifurcation Analysis and Nonlinear Decay of a Tumor in the Presence of an Immune Response ⋮ Global stability and tumor clearance conditions for a cancer chemotherapy system ⋮ Interactions between the immune system and cancer: A brief review of non-spatial mathematical models ⋮ New observations on optimal cancer treatments for a fractional tumor growth model with and without singular kernel ⋮ On a multiobjective optimal control of a tumor growth model with immune response and drug therapies ⋮ A Cancer Model for the Angiogenic Switch and Immunotherapy: Tumor Eradication in Analysis of Ultimate Dynamics ⋮ A computational study of combination HIFU-chemotherapy as a potential means of overcoming cancer drug resistance ⋮ OPTIMAL CONTROL OF MIXED IMMUNOTHERAPY AND CHEMOTHERAPY OF TUMORS ⋮ What can be learned from a chaotic cancer model? ⋮ Parameter identification of a model for prostate cancer treated by intermittent therapy ⋮ New numerical surfaces to the mathematical model of cancer chemotherapy effect in Caputo fractional derivatives ⋮ Bounding the dynamics of a chaotic-cancer mathematical model ⋮ Bridging blood cancers and inflammation: the reduced cancitis model ⋮ Optimal control homotopy perturbation method for cancer model ⋮ Optimal CAR T-cell immunotherapy strategies for a leukemia treatment model ⋮ Optimal control problem for a general reaction-diffusion tumor-immune system with chemotherapy ⋮ Dynamical behaviour of a tumor-immune system with chemotherapy and optimal control ⋮ A survey of optimization models on cancer chemotherapy treatment planning ⋮ Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls ⋮ Modelling pulsed immunotherapy of tumour-immune interaction ⋮ Fastest time to cancer by loss of tumor suppressor genes ⋮ A validated mathematical model of tumor growth including tumor-host interaction, cell-mediated immune response and chemotherapy ⋮ An optimal control approach for blood pressure regulation during head-up tilt ⋮ A mathematical model of tumour growth with Beddington–DeAngelis functional response: a case of cancer without disease ⋮ Bone metastasis treatment modeling via optimal control ⋮ Identification of some unknown parameters in an aggressive-invasive cancer model using adjoint approach ⋮ Stability and Hopf bifurcations in a competitive tumour-immune system with intrinsic recruitment delay and chemotherapy ⋮ Chaos and optimal control of cancer self-remission and tumor system steady states ⋮ Bifurcation analysis of a delayed mathematical model for tumor growth ⋮ PARRONDO'S GAME MODEL TO FIND NUMERICALLY STABLE ATTRACTORS OF A TUMOR GROWTH MODEL ⋮ Robust p53 recovery using chattering free sliding mode control and a gain-scheduled modified utkin observer ⋮ Chaos control in three dimensional cancer model by state space exact linearization based on Lie algebra ⋮ Optimal chemotherapy in cancer treatment: state dependent Riccati equation control and extended Kalman filter ⋮ On Some Dynamical Properties of a Seven-Dimensional Cancer Model with Immunotherapy ⋮ Evolution of a mathematical model of an aggressive-invasive cancer under chemotherapy ⋮ Dynamic analysis of a tumor-immune system under Allee effect ⋮ Delay differential model for tumour-immune response with chemoimmunotherapy and optimal control ⋮ Optimal control of tumour-immune model with time-delay and immuno-chemotherapy ⋮ Spatial avascular growth of tumor in a homogeneous environment ⋮ The dynamics of war between benign cells, malignant cells, and killer agents ⋮ Optimal control of the dynamics of a tumor growth model with Hollings' type-II functional response ⋮ A mathematical model for the effect of obesity on cancer growth and on the immune system response ⋮ A Feedback Control Model of Comprehensive Therapy for Treating Immunogenic Tumours ⋮ Modelling of tumor cells regression in response to chemotherapeutic treatment ⋮ A cancer model for the angiogenic switch ⋮ Hopf bifurcation, cascade of period-doubling, chaos, and the possibility of cure in a 3D cancer model ⋮ On the global dynamics of one cancer tumour growth model ⋮ Tumor Stabilization Induced by T-Cell Recruitment Fluctuations ⋮ Chaotic dynamics of a delayed tumor–immune interaction model ⋮ Bifurcation Analysis in a Cancer Growth Model ⋮ Nonnegative solutions of systems with fractional-rational right-hand sides and localization of attractors ⋮ A two-compartment model interacting with dynamic drugs ⋮ ON THE GLOBAL DYNAMICS OF THE OWEN–SHERRATT MODEL DESCRIBING THE TUMOR–MACROPHAGE INTERACTIONS ⋮ PERIODICALLY PULSED IMMUNOTHERAPY IN A MATHEMATICAL MODEL OF TUMOR-IMMUNE INTERACTION ⋮ Two-compartment model interacting with proliferating regulatory factor ⋮ Mixed therapy in cancer treatment for personalized drug administration using model reference adaptive control ⋮ Analyzing the quality robustness of chemotherapy plans with respect to model uncertainties ⋮ A NEW MATHEMATICAL MODELING AND SUB-OPTIMAL CHEMOTHERAPY OF CANCER
Cites Work
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Unnamed Item
- Optimal control for a cancer chemotherapy problem with general growth and loss functions
- Mathematical model of cancer chemotherapy. Periodic schedules of phase- specific cytotoxic-agent administration increasing the selectivity of therapy
- Modeling immunotherapy of the tumor -- immune interaction
- Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
- Singularity of optimal control in some problems related to optimal chemotherapy
- Asymptotically autonomous differential equations in the plane
- Optimal drug regimens in cancer chemotherapy for single drugs that block progression through the cell cycle
- Chemotherapeutic treatments: A study of the interplay among drug resistance, toxicity and recuperation from side effects
- Conflicting objectives in chemotherapy with drug resistance
- A logistic model of periodic chemotherapy with drug resistance
- The influence of fixed and free final time of treatment on optimal chemotherapeutic protocols
- Modelling and mathematical problems related to tumor evolution and its interaction with the immune system
- Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity
- Cancer chemotherapy optimization under evolving drug resistance.
- Balancing survival and extinction in nonautonomous competitive Lotka- Volterra systems
- A simple mathematical model and alternative paradigm for certain chemotherapeutic regimens
- A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment
- A mathematical model of cancer treatment by immunotherapy
- A mathematical model of cancer chemotherapy with an optimal selection of parameters
- The dynamics of growth-factor-modified immune response to cancer growth: One dimensional models
- A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach
- Systems of differential equations which are competitive or cooperative: III. Competing species
- Extinction in nonautonomous competitive Lotka-Volterra systems
- Extinction in Competitive Lotka-Volterra Systems
- Three-Dimensional Competitive Lotka--Volterra Systems with no Periodic Orbits
- TUMOR/IMMUNE SYSTEM COMPETITION WITH MEDICALLY INDUCED ACTIVATION/DEACTIVATION
- MATHEMATICAL MODELLING OF MACROPHAGE DYNAMICS IN TUMOURS
- USING COMPUTER SIMULATIONS FOR EVALUATING THE EFFICACY OF BREAST CANCER CHEMOTHERAPY PROTOCOLS
- Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy
- Modeling tumor regrowth and immunotherapy