Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity

DOI10.1016/0025-5564(94)00028-XzbMATH Open0821.92016OpenAlexW2018370216WikidataQ52351072 ScholiaQ52351072MaRDI QIDQ1804872FDOQ1804872

M. I. S. Costa, J. L. Boldrini, Rodney C. Bassanezi

Publication date: 27 September 1995

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(94)00028-x

zbMATH Keywords

cancer chemotherapydrug resistanceexponential tumor growthtoxicitycontrol of tumor cells growth

Mathematics Subject Classification ID

Medical applications (general) (92C50) Differential games and control (49N70) Pursuit and evasion games (49N75) Optimality conditions for problems involving ordinary differential equations (49K15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Role of optimal control theory in cancer chemotherapy
• A model for the resistance of tumor cells to cancer chemotherapeutic agents
• A stochastic model for the origin and treatment of tumors containing drug-resistant cells
• Drug kinetics and drug resistance in optimal chemotherapy
• Mathematical approaches to optimization of cancer chemotherapy
• Optimal control for a cancer chemotherapy problem with general growth and loss functions
• Some optimal control problems in cancer chemotherapy with a toxicity limit
• Optimal control in some cancer chemotherapy problems
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Cited In (15)

• The influence of fixed and free final time of treatment on optimal chemotherapeutic protocols
• Drug kinetics and drug resistance in optimal chemotherapy
• Phenomenological model of tumors
• Solution of the feedback control problem in the mathematical model of leukaemia therapy
• Computational modeling of tumor response to vascular-targeting therapies. I: Validation
• The dynamics of an optimally controlled tumor model: A case study
• Recovery of normal hemopoiesis in disseminated cancer therapy -- a model
• Title not available (Why is that?)
• Optimal multitherapy strategy in mathematical model of dynamics of the number of nonuniform tumor cells
• Chemotherapeutic treatments: A study of the interplay among drug resistance, toxicity and recuperation from side effects
• A chemotherapy model for the treatment of cancer with metastasis
• The optimal dose of CAF regimen in adjuvant chemotherapy for breast cancer patients at stage IIB
• Conflicting objectives in chemotherapy with drug resistance
• On strategies on a mathematical model for leukemia therapy
• Maximization of viability time in a mathematical model of cancer therapy

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