Drug kinetics and drug resistance in optimal chemotherapy

DOI10.1016/0025-5564(94)00027-WMaRDI QIDQ1804871zbMATH OpenOpenAlexWikidataFDO

Authors M. I. S. Costa, J. L. Boldrini, Rodney C. Bassanezi

Publication date 27 September 1995

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(94)00027-w

zbMATH Keywords

saturationtumor growthdrug resistancetoxicitydrug concentrationdrug decayfirst-order pharmacokinetics dynamicsmaximum allowed drug injectionoptimal chemotherapy

Mathematics Subject Classification ID

Medical applications (general) (92C50) Differential games and control (49N70) Pursuit and evasion games (49N75) Optimality conditions for problems involving ordinary differential equations (49K15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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• scientific article; zbMATH DE number 3297399 (Why is no real title available?)
• A model for the resistance of tumor cells to cancer chemotherapeutic agents
• A stochastic model for the origin and treatment of tumors containing drug-resistant cells
• Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity
• Novel approach for determining optimal treatment regimen for cancer c𝕙emotherapy
• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Role of optimal control theory in cancer chemotherapy

Cited in

(14)

• The influence of fixed and free final time of treatment on optimal chemotherapeutic protocols
• Drug resistance in cancer chemotherapy as an optimal control problem
• Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity
• Two optimal control problems in cancer chemotherapy with drug resistance
• ANALYSIS OF A CELL-CYCLE SPECIFIC MODEL FOR CANCER CHEMOTHERAPY
• Optimization of the chemotherapy process on the base of the maximum principle
• Numerical optimisation of chemotherapy dosage under antiangiogenic treatment in the presence of drug resistance
• Application of optimal control theory to analysis of cancer chemotherapy regimens
• Analysis of resonance chemotherapy in leukemia treatment via multi-staged population balance models
• A cellular automata model of chemotherapy effects on tumour growth: targeting cancer and immune cells
• Optimal multitherapy strategy in mathematical model of dynamics of the number of nonuniform tumor cells
• Models for dose intensity
• Chemotherapeutic treatments: A study of the interplay among drug resistance, toxicity and recuperation from side effects
• Conflicting objectives in chemotherapy with drug resistance

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