Chemotherapeutic treatments: A study of the interplay among drug resistance, toxicity and recuperation from side effects

DOI10.1007/BF02462001zbMATH Open0899.92024MaRDI QIDQ1361432FDOQ1361432

Authors: M. I. S. Costa, J. L. Boldrini 

Publication date: 1997

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

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zbMATH Keywords

cancer chemotherapydrug resistancecontrol of tumor growth

Mathematics Subject Classification ID

Medical applications (general) (92C50) Differential games and control (49N70) Pursuit and evasion games (49N75) Control/observation systems governed by ordinary differential equations (93C15)

Cites Work

• Optimization and nonsmooth analysis
• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• Tumor growth \textit{in vivo} and as multicellular spheroids compared by mathematical models
• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Role of optimal control theory in cancer chemotherapy
• A model for the resistance of tumor cells to cancer chemotherapeutic agents
• A stochastic model for the origin and treatment of tumors containing drug-resistant cells
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• Drug kinetics and drug resistance in optimal chemotherapy
• Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity
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• Dynamics of tumor interaction with the host immune system
• Mathematical approaches to optimization of cancer chemotherapy
• Optimal control for a cancer chemotherapy problem with general growth and loss functions
• Some optimal control problems in cancer chemotherapy with a toxicity limit
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Cited In (10)

• Dynamical analysis of chemotherapy models with time-dependent infusion
• A survey of optimization models on cancer chemotherapy treatment planning
• A mathematical model of chemotherapy with variable infusion
• The dynamics of an optimally controlled tumor model: A case study
• TUMOR/IMMUNE SYSTEM COMPETITION WITH MEDICALLY INDUCED ACTIVATION/DEACTIVATION
• TUMOR/IMMUNE SYSTEM COMPETITION WITH MEDICALLY INDUCED ACTIVATION/DEACTIVATION
• Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures
• Stability analysis of a chemotherapy model with delays
• Conflicting objectives in chemotherapy with drug resistance
• The dynamics of war between benign cells, malignant cells, and killer agents

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