OPTIMAL CONTROL OF MIXED IMMUNOTHERAPY AND CHEMOTHERAPY OF TUMORS

DOI10.1142/S0218339008002435zbMath1147.92020MaRDI QIDQ3530573

L. G. de Pillis, Weiqing Gu, K. Renee Fister, Kenji Kozai, Tiffany Head, Kenny Maples, Todd Neal, Anand Murugan

Publication date: 20 October 2008

Published in: Journal of Biological Systems (Search for Journal in Brave)

zbMATH Keywords

quadratic optimal control; mixed-immuno-chemotherapy

Mathematics Subject Classification ID

49N90: Applications of optimal control and differential games

92C50: Medical applications (general)

49K15: Optimality conditions for problems involving ordinary differential equations

Related Items

In silico synergism and antagonism of an anti-tumour system intervened by coupling immunotherapy and chemotherapy: a mathematical modelling approach, Optimal control for selected cancer chemotherapy ODE models: a view on the potential of optimal schedules and choice of objective function

Uses Software

• XPPAUT

Cites Work

• Unnamed Item
• Optimal control in a model of dendritic cell transfection cancer immunotherapy
• Modeling immunotherapy of the tumor -- immune interaction
• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas
• A model of tumor and lymphocyte interactions
• The dynamics of an optimally controlled tumor model: A case study
• Differential equations. Classical to controlled
• Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls
• Simulating, Analyzing, and Animating Dynamical Systems
• Comparison of optimal controls for a model in cancer chemotherapy withL₁- andL₂-type objectives