Optimizing the timing and composition of therapeutic phage cocktails: a control-theoretic approach

DOI10.1101/845172MaRDI QIDQ2189975zbMATH OpenOpenAlexWikidataFDO

Authors Laurent Debarbieux, Joshua S. Weitz, Guan Lin Li, Chung Yin (Joey) Leung, Y. Wardi

Publication date 17 June 2020

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/s11538-020-00751-w

zbMATH Keywords

mathematical modelingoptimal control theoryphage therapy

Mathematics Subject Classification ID

Existence theories for optimal control problems involving ordinary differential equations (49J15) Medical applications (general) (92C50)

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Cited in

(5)

• Modeling the synergistic elimination of bacteria by phage and the innate immune system
• Phage-antibiotic synergy inhibited by temperate and chronic virus competition
• Optimal bacteriophage mutation rates for phage therapy
• Oncolytic virus treatment of human breast cancer cells: modelling therapy efficacy
• A nonlinear optimal control approach for bacterial infections under antibiotics resistance

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