Phage-antibiotic synergy inhibited by temperate and chronic virus competition

DOI10.1007/S11538-022-01006-6MaRDI QIDQ2127650zbMATH OpenOpenAlexWikidataFDO

Authors Kylie J. Landa, Lauren M. Mossman, Rachel Whitaker, Zoi Rapti, Sara M. Clifton

Publication date 21 April 2022

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2104.08989

zbMATH Keywords

\textit{Pseudomonas aeruginosa}bacteriabacteriophagecystic fibrosisevasioninfectionlatentlyticmathematical modelphagepopulation dynamicsrecoveryresistance

Mathematics Subject Classification ID

Microbiology (92C70)

Abstract: As antibiotic resistance grows more frequent for common bacterial infections, alternative treatment strategies such as phage therapy have become more widely studied in the medical field. While many studies have explored the efficacy of antibiotics, phage therapy, or synergistic combinations of phages and antibiotics, the impact of virus competition on the efficacy of antibiotic treatment has not yet been considered. Here, we model the synergy between antibiotics and two viral types, temperate and chronic, in controlling bacterial infections. We demonstrate that while combinations of antibiotic and temperate viruses exhibit synergy, competition between temperate and chronic viruses inhibits bacterial control with antibiotics. In fact, our model reveals that antibiotic treatment may counterintuitively increase the bacterial load when a large fraction of the bacteria develop antibiotic-resistance.

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Cites work

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Cited in

(6)

• Mutual inhibition in presence of a virus in continuous culture
• Temperate and chronic virus competition leads to low lysogen frequency
• Non-conventional therapeutic technique to replace CRISPR bacteria from biofilm by inducible lysogen
• Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments
• Within-host mathematical modeling of antibiotic-phage treatments on lysogenic and nonlysogenic bacteria dynamics
• The population biology of bacterial viruses: Why be temperate

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