A methodology for performing global uncertainty and sensitivity analysis in systems biology

From MaRDI portal
Publication:1797427

DOI10.1016/j.jtbi.2008.04.011zbMath1400.92013OpenAlexW2152803686WikidataQ37197756 ScholiaQ37197756MaRDI QIDQ1797427

Denise E. Kirschner, Christian J. Ray, Ian B. Hogue, Simeone Marino

Publication date: 22 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc2570191




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can help eradicate hepatitis B in ChinaSensitivity and Robustness Analysis for Stochastic Model of Nanog Gene Regulatory NetworkMathematical modelling of autoimmune myocarditis and the effects of immune checkpoint inhibitorsImpact of estrogen population pharmacokinetics on a QSP model of mammary stem cell differentiation into myoepithelial cellsModeling the host response to inhalation anthraxParameter inference for an individual based model of chytridiomycosis in frogsA co-infection model on TB - COVID-19 with optimal control and sensitivity analysisGlobal sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responsesModeling the effects of systemic mediators on the inflammatory phase of wound healingA computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatmentRestoration of cytosolic calcium inhibits \textit{Mycobacterium tuberculosis} intracellular 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environmental contamination on the dynamical transmission of polioA population model capturing dynamics of tuberculosis granulomas predicts host infection outcomesQuantifying the impact of decay in bed-net efficacy on malaria transmissionModelling the transmission dynamics of dengue in the presence of \textit{Wolbachia}Global sensitivity analysis used to interpret biological experimental resultsModelling the dynamics of CaMKII-NMDAR complex related to memory formation in synapses: the possible roles of threonine 286 autophosphorylation of CaMKII in long term potentiation



Cites Work