Experimental data and PBPK modeling quantify antibody interference in PEGylated drug carrier delivery

DOI10.1007/S11538-021-00950-ZMaRDI QIDQ2051453zbMATH OpenOpenAlexWikidataFDO

Authors Anne M. Talkington, Timothy Wessler, S. K. Lai, Y. G. Cao, M. Gregory Forest

Publication date 24 November 2021

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-021-00950-z

zbMATH Keywords

anti-PEG antibodiesLatin hypercube samplingparameter optimizationPBPK modelpegylated liposomes

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Recommendations

• scientific article; zbMATH DE number 1254061
• A computational investigation of the ventilation structure and maximum rate of metabolism for a physiologically based pharmacokinetic (PBPK) model of inhaled xylene
• Uncertainty, Variability, and Sensitivity Analysis in Physiological Pharmacokinetic Models
• Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs
• A mechanistic compartmental model for total antibody uptake in tumors

Cites work

• A Comparison of Three Methods for Selecting Values of Input Variables in the Analysis of Output from a Computer Code
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Parameter estimation on a stochastic SIR model with media coverage

Cited in

(4)

• Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
• RECEPTOR-MEDIATED ENDOCYTOSIS MODELING OF ANTIBODY-DRUG CONJUGATES TO THE RELEASED PAYLOAD WITHIN THE INTRACELLULAR SPACE CONSIDERING TARGET ANTIGEN EXPRESSION LEVELS
• Local identifiability analysis, parameter subset selection and verification for a minimal brain PBPK model

Describes a project that uses

Uses Software

• GitHub

This page was built for publication: Experimental data and PBPK modeling quantify antibody interference in PEGylated drug carrier delivery

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2051453)