Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency

DOI10.1016/J.JTBI.2011.04.030MaRDI QIDQ1783553zbMATH OpenOpenAlexWikidataFDO

Authors Philip J. Aston, Gianne Derks, A. Raji, Balaji M. Agoram, Piet H. van der Graaf

Publication date 21 September 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2011.04.030

zbMATH Keywords

affinityefficacytarget-mediated drug dispositionpharmacologyIgE

Mathematics Subject Classification ID

Medical applications (general) (92C50) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cited in

(14)

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• Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC
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• Challenges in pharmacology modelling
• An importance sampling approach for reliable and efficient inference in Bayesian ordinary differential equation models
• Global dynamics of target-mediated drug disposition models and their solutions by nonstandard finite difference method
• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
• Network biology in development of monoclonal antibody therapeutics
• A mathematical analysis of rebound in a target-mediated drug disposition model. II. With feedback
• A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback
• Topics in mathematical pharmacology
• Slow invariant manifolds of fast-slow systems of ODEs with physics-informed neural networks

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