Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC
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Publication:1649441
DOI10.1016/j.jtbi.2018.01.028zbMath1397.92275WikidataQ50153374 ScholiaQ50153374MaRDI QIDQ1649441
Publication date: 6 July 2018
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.01.028
half-life; area under the curve (AUC); monoclonal antibodies (mAbs); pharmacokinetics and pharmacodynamics (PKPD); target mediated drug disposition (TMDD)
92C45: Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.)
92C40: Biochemistry, molecular biology
34D23: Global stability of solutions to ordinary differential equations
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Cites Work
- Dynamics of target-mediated drug disposition: how a drug reaches its target
- Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
- A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback