Dynamics of target-mediated drug disposition: how a drug reaches its target

DOI10.1007/s10596-012-9312-4zbMath1392.92034OpenAlexW2033332673MaRDI QIDQ723281

Lambertus A. Peletier, Johan Gabrielsson

Publication date: 30 July 2018

Published in: Computational Geosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10596-012-9312-4

zbMATH Keywords

singular perturbationspharmacokineticsMichaelis-Mentenreceptor-binding

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Computational methods for problems pertaining to biology (92-08)

Related Items

Challenges in pharmacology modelling, Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC, A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback, Asymptotic analysis of a TMDD model: when a reaction contributes to the destruction of its product, A mathematical analysis of rebound in a target-mediated drug disposition model. II. With feedback, Geometric singular perturbation analysis of a dynamical target mediated drug disposition model

Cites Work

• On the validity of the steady state assumption of enzyme kinetics
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
• Impact of plasma-protein binding on receptor occupancy: an analytical description
• The Quasi-Steady-State Assumption: A Case Study in Perturbation