Dynamics of target-mediated drug disposition: how a drug reaches its target

DOI10.1007/S10596-012-9312-4MaRDI QIDQ723281zbMATH OpenOpenAlexFDO

Authors Lambertus A. Peletier, Johan Gabrielsson

Publication date 30 July 2018

Published in Computational Geosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s10596-012-9312-4

zbMATH Keywords

singular perturbationspharmacokineticsMichaelis-Mentenreceptor-binding

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Computational methods for problems pertaining to biology (92-08) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Impact of plasma-protein binding on receptor occupancy: an analytical description
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
• On the validity of the steady state assumption of enzyme kinetics
• The Quasi-Steady-State Assumption: A Case Study in Perturbation

Cited in

(11)

• A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback
• Selecting optimal drug-intervention in a pathway involving receptor tyrosine kinases (RTKs)
• Challenges in pharmacology modelling
• Modeling drug-protein dynamics
• A mathematical analysis of rebound in a target-mediated drug disposition model. II. With feedback
• Dynamics of a two-receptor binding model: how affinities and capacities translate into long and short time behaviour and physiological corollaries
• Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
• Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC
• Monotonicity of time to peak response with respect to drug dose for turnover models
• Geometric singular perturbation analysis of a dynamical target mediated drug disposition model
• Asymptotic analysis of a TMDD model: when a reaction contributes to the destruction of its product

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