The Quasi-Steady-State Assumption: A Case Study in Perturbation

DOI10.1137/1031091zbMATH Open0679.34066DBLPjournals/siamrev/SegelS89OpenAlexW2002164453WikidataQ56210926 ScholiaQ56210926MaRDI QIDQ4728679FDOQ4728679

Authors: Lee A. Segel, Marshall Slemrod 

Publication date: 1989

Published in: SIAM Review (Search for Journal in Brave)

Full work available at URL: https://zenodo.org/record/1059052

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zbMATH Keywords

error estimatesscalingquasi-steady-state assumptionMichaelis-Menten approximationfast transient

Mathematics Subject Classification ID

Singular perturbations for ordinary differential equations (34E15) Singular perturbations of ordinary differential equations (34D15) Physiological, cellular and medical topics (92Cxx)

Cited In (only showing first 100 items - show all)

• Quasi-steady-state laws in reversible model of enzyme kinetics
• Enzyme kinetics far from the standard quasi-steady-state and equilibrium approximations
• Data-driven non-Markovian closure models
• On the validity of the steady state assumption of enzyme kinetics
• Reduction of a kinetic model of active export of importins
• A simplified perturbation solution of Michaelis-Menten kinetics equations in a ``total framework
• A theoretical and experimental study of competition between solution and surface receptors for ligand in a Biacore flow cell
• Asymptotic methods for reaction-diffusion systems: past and present
• The QSSA in chemical kinetics: as taught and as practiced
• Outbreak analysis of an SIS epidemic model with rewiring
• The Michaelis-Menten-Stueckelberg theorem
• Time dependent solution for acceleration of tau-leaping
• Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios
• Enzyme kinetics of multiple alternative substrates
• Bandwidth sharing networks with multiscale traffic
• The \(G\)-scheme: a framework for multi-scale adaptive model reduction
• Reversible-equivalent-monomolecular tau: a leaping method for ``small number and stiff stochastic chemical systems
• Extinction threshold for spatial forest dynamics with height structure
• On the Lambert \(w\) function
• A study case for the analysis of asymptotic expansions beyond the tQSSA for inhibitory mechanisms in enzyme kinetics.
• Challenges in pharmacology modelling
• A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentation
• An improved method to measure all rate constants in the simplest enzyme kinetics model
• Tikhonov's theorem and quasi-steady state
• Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?
• Scaling in biochemical kinetics: Dissection of a relaxation oscillator
• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Plant-pollinator population dynamics
• Multiscale stochastic simulation algorithm with stochastic partial equilibrium assumption for chemically reacting systems
• A novel approach to measure all rate constants in the simplest enzyme kinetics model
• Computational singular perturbation analysis of stochastic chemical systems with stiffness
• Effects of quasi-steady-state reduction on biophysical models with oscillations
• The steady-state assumption in oscillating and growing systems
• Error propagation in approximations to reaction-diffusion-advection equations.
• Quasi steady state and partial equilibrium approximations: their relation and their validity
• The total quasi-steady-state approximation is valid for reversible enzyme kinetics
• Asymptotic analysis of two reduction methods for systems of chemical reactions
• Extending the quasi-steady state approximation by changing variables
• A note on the kinetics of suicide substrates
• Computing quasi-steady state reductions
• The total quasi-steady-state approximation for complex enzyme reactions
• A constructive approach to quasi-steady state reductions
• Effective rate models for the analysis of transport-dependent biosensor data
• Individually-based Markov processes modeling nonlinear systems in mathematical biology
• Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution
• Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
• A spatial model of cellular molecular trafficking including active transport along microtubules
• Reduced models of networks of coupled enzymatic reactions
• Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology
• Separation of time-scales and model reduction for stochastic reaction networks
• Sufficient Conditions for Coordination of Coupled Nonlinear Biochemical Systems: Analysis of a Simple, Representative Example
• On the validity of the quasi-steady state approximation of bimolecular reactions in solution
• Solving linear unbranched pathways with Michaelis-Menten kinetics using the Lambert \(W\)-function
• A geometric analysis of fast-slow models for stochastic gene expression
• The kinetics of enzyme systems involving activation of zymogens
• Partial equilibrium approximations in apoptosis. I: The intracellular-signaling subsystem
• Asymptotic expansions in enzyme reactions with high enzyme concentrations
• A perturbation solution of Michaelis-Menten kinetics in a ``total framework
• Three level signal transduction cascades lead to reliably timed switches
• Invariant manifolds for random dynamical systems with slow and fast variables
• Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2
• Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity
• Rescue of the Quasi‐Steady‐State Approximation in a Model for Oscillations in an Enzymatic Cascade
• Quasi-steady state and nearly invariant sets
• The total quasi-steady-state approximation for fully competitive enzyme reactions
• Nonstandard finite difference schemes for Michaelis--Menten type reaction-diffusion equations
• Properties of the Michaelis-Menten mechanism in phase space
• Quasi-steady state in the Michaelis-Menten system
• The role of slow system dynamics in predicting the degeneracy of slow invariant manifolds: the case of vdP relaxation-oscillations
• Quasi-steady-state approximation for a reaction-diffusion system with fast intermediate
• On approximate analytical solutions of differential equations in enzyme kinetics using homotopy perturbation method
• Tuberculosis models with fast and slow dynamics: The role of close and casual contacts
• Data-Driven Reduction for a Class of Multiscale Fast-Slow Stochastic Dynamical Systems
• A spatial physiological model for p53 intracellular dynamics
• Dimensionality reduction of bistable biological systems
• Determining ``small parameters for quasi-steady state
• Reduction of linear kinetic systems with multiple scales
• Quasi-steady-state approximation for reaction-diffusion equations
• Glycolysis in saccharomyces cerevisiae: algorithmic exploration of robustness and origin of oscillations
• Instantaneous limits of reversible chemical reactions in presence of macroscopic convection.
• Singular perturbations and scaling
• On the anti-quasi-steady-state conditions of enzyme kinetics
• A kinetic analysis of coupled (or auxiliary) enzyme reactions
• The Status of the QSSA Approximation in Stochastic Simulations of Reaction Networks
• From enzyme kinetics to epidemiological models with Michaelis-Menten contact rate: design of nonstandard finite difference schemes
• Some nonstandard modeling techniques in theoretical biology
• Asymptotics of conduction velocity restitution in models of electrical excitation in the heart
• Approximation and inference methods for stochastic biochemical kinetics -- a tutorial review
• Efficacy of quasi-steady-state approximation in Michaelis-Menten kinetics: a stochastic signature
• Operating regimes of covalent modification cycles at high enzyme concentrations
• Modeling the action of drugs on cellular enzymes by means of optimal control techniques
• Single-substrate enzyme kinetics: the quasi-steady-state approximation and beyond
• Effects of periodic input on the quasi-steady state assumptions for enzyme-catalysed reactions
• Limits of noise for autoregulated gene expression
• Mathematical modelling of metapopulation dynamics: revisiting its meaning
• Critical parameters for singular perturbation reductions of chemical reaction networks
• Thresholds for disease persistence in models for tick-borne infections including non-viraemic transmission, extended feeding and tick aggregation
• Multi-timescale systems and fast-slow analysis
• On the validity and errors of the pseudo-first-order kinetics in ligand-receptor binding
• Slow-scale tau-leaping method

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