The Quasi-Steady-State Assumption: A Case Study in Perturbation

DOI10.1137/1031091MaRDI QIDQ4728679zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Lee A. Segel, Marshall Slemrod

Publication date 1989

Published in SIAM Review (Search for Journal in Brave)

Full work available at URL https://zenodo.org/record/1059052

zbMATH Keywords

error estimatesscalingquasi-steady-state assumptionMichaelis-Menten approximationfast transient

Mathematics Subject Classification ID

Singular perturbations for ordinary differential equations (34E15) Singular perturbations of ordinary differential equations (34D15) Physiological, cellular and medical topics (92Cxx)

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Cited in

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• Instantaneous limits of reversible chemical reactions in presence of macroscopic convection.
• Quasi-steady-state laws in reversible model of enzyme kinetics
• MOLECULAR REPLICATOR DYNAMICS
• The unreasonable effectiveness of the total quasi-steady state approximation, and its limitations
• Rigorous estimates for the quasi-steady state approximation of the Michaelis-Menten reaction mechanism at low enzyme concentrations
• Enzyme kinetics far from the standard quasi-steady-state and equilibrium approximations
• Data-driven non-Markovian closure models
• A population dynamics model of mosquito-borne disease transmission, focusing on mosquitoes' biased distribution and mosquito repellent use
• On the validity of the steady state assumption of enzyme kinetics
• Point island dynamics under fixed rate deposition
• Reduction of a kinetic model of active export of importins
• A theoretical and experimental study of competition between solution and surface receptors for ligand in a Biacore flow cell
• Asymptotic methods for reaction-diffusion systems: past and present
• Competitive effects in bacterial mRNA decay
• A simplified perturbation solution of Michaelis-Menten kinetics equations in a ``total framework
• Outbreak analysis of an SIS epidemic model with rewiring
• Maini's many contributions to mathematical enzyme kinetics: a review
• The Michaelis-Menten-Stueckelberg theorem
• Singular perturbations and scaling
• The QSSA in chemical kinetics: as taught and as practiced
• From enzyme kinetics to epidemiological models with Michaelis-Menten contact rate: design of nonstandard finite difference schemes
• A kinetic analysis of coupled (or auxiliary) enzyme reactions
• On the anti-quasi-steady-state conditions of enzyme kinetics
• Multiscale malaria models and their uniform in-time asymptotic analysis
• Time dependent solution for acceleration of tau-leaping
• Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios
• Reduction of Chemical Reaction Networks with Approximate Conservation Laws
• The Status of the QSSA Approximation in Stochastic Simulations of Reaction Networks
• Some nonstandard modeling techniques in theoretical biology
• Reversible-equivalent-monomolecular tau: a leaping method for ``small number and stiff stochastic chemical systems
• Enzyme kinetics of multiple alternative substrates
• The Rosenzweig-MacArthur system via reduction of an individual based model
• Asymptotics of conduction velocity restitution in models of electrical excitation in the heart
• The \(G\)-scheme: a framework for multi-scale adaptive model reduction
• Bandwidth sharing networks with multiscale traffic
• Extinction threshold for spatial forest dynamics with height structure
• Slow invariant manifolds of singularly perturbed systems via physics-informed machine learning
• Operating regimes of covalent modification cycles at high enzyme concentrations
• Approximation and inference methods for stochastic biochemical kinetics -- a tutorial review
• Efficacy of quasi-steady-state approximation in Michaelis-Menten kinetics: a stochastic signature
• Challenges in pharmacology modelling
• A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentation
• Modeling the action of drugs on cellular enzymes by means of optimal control techniques
• On the Lambert \(w\) function
• A study case for the analysis of asymptotic expansions beyond the tQSSA for inhibitory mechanisms in enzyme kinetics.
• A method of `speed coefficients' for biochemical model reduction applied to the NF-\(\kappa\)B system
• Single-substrate enzyme kinetics: the quasi-steady-state approximation and beyond
• An improved method to measure all rate constants in the simplest enzyme kinetics model
• Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?
• Tikhonov's theorem and quasi-steady state
• Effects of periodic input on the quasi-steady state assumptions for enzyme-catalysed reactions
• Limits of noise for autoregulated gene expression
• Diffusion fronts in enzyme-catalysed reactions
• Fast reactions with non-interacting species in stochastic reaction networks
• Scaling in biochemical kinetics: Dissection of a relaxation oscillator
• Bifurcation analysis of Wilson-Cowan model with singular impulses
• Natural parameter conditions for singular perturbations of chemical and biochemical reaction networks
• Critical parameters for singular perturbation reductions of chemical reaction networks
• Analysis of Dynamics of a Biphasic Isothermal DNA Amplification Reaction
• Heineken, Tsuchiya and Aris: ``On the mathematical status of the pseudo-steady state hypothesis. A classic from Volume 1 of \textit{Mathematical Biosciences}
• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Mathematical modelling of metapopulation dynamics: revisiting its meaning
• Plant-pollinator population dynamics
• Asymptotic Analysis of a Silicon Furnace Model
• Thresholds for disease persistence in models for tick-borne infections including non-viraemic transmission, extended feeding and tick aggregation
• Two different types of kinetics, where the initial rate increases faster or slower than the reactant concentration, can coexist on bell-shaped kinetic dependencies
• Uniform approximation of solutions by elimination of intermediate species in deterministic reaction networks
• Slow-scale tau-leaping method
• Multi-timescale systems and fast-slow analysis
• On the validity and errors of the pseudo-first-order kinetics in ligand-receptor binding
• Stochastic enzyme kinetics and the quasi-steady-state reductions: application of the slow scale linear noise approximation à la Fenichel
• Classical quasi-steady state reduction -- a mathematical characterization
• Algorithmic reduction of biological networks with multiple time scales
• Impact of enzyme turnover on the dynamics of the Michaelis-Menten model
• Rigorous derivation of Michaelis-Menten kinetics in the presence of slow diffusion
• scientific article; zbMATH DE number 2102658 (Why is no real title available?)
• The potential roles of transacylation in intracellular lipolysis and related Qssa approximations
• Automatic simplification of systems of reaction-diffusion equations by \textit{a posteriori} analysis
• Multiscale stochastic simulation algorithm with stochastic partial equilibrium assumption for chemically reacting systems
• Uniform asymptotic expansions beyond the tQSSA for the Goldbeter-Koshland switch
• A novel approach to measure all rate constants in the simplest enzyme kinetics model
• Effects of quasi-steady-state reduction on biophysical models with oscillations
• The steady-state assumption in oscillating and growing systems
• The total quasi-steady state assumption: its justification by singular perturbation theory and its application to the chemical master equation
• On a stochastic approach to model the double phosphorylation/dephosphorylation cycle
• Computational singular perturbation analysis of stochastic chemical systems with stiffness
• A geometric method for model reduction of biochemical networks with polynomial rate functions
• Modeling disease transmission near eradication: an equation free approach
• A coordinate-independent version of Hoppensteadt's convergence theorem
• An alternative approach to Michaelis-Menten kinetics that is based on the renormalization group
• Error propagation in approximations to reaction-diffusion-advection equations.
• The total quasi-steady-state for multiple alternative substrate reactions
• On the stability of a class of Michaelis-Menten networks
• Asymptotic analysis of two reduction methods for systems of chemical reactions
• The total quasi-steady-state approximation is valid for reversible enzyme kinetics
• A note on the kinetics of suicide substrates
• Computing quasi-steady state reductions
• Extending the quasi-steady state approximation by changing variables
• A constructive approach to quasi-steady state reductions
• Quasi steady state and partial equilibrium approximations: their relation and their validity

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