The Quasi-Steady-State Assumption: A Case Study in Perturbation

DOI10.1137/1031091zbMATH Open0679.34066DBLPjournals/siamrev/SegelS89OpenAlexW2002164453WikidataQ56210926 ScholiaQ56210926MaRDI QIDQ4728679FDOQ4728679

Authors: Lee A. Segel, Marshall Slemrod 

Publication date: 1989

Published in: SIAM Review (Search for Journal in Brave)

Full work available at URL: https://zenodo.org/record/1059052

Recommendations

• Quasi-steady state: searching for and utilizing small parameters
• The total quasi-steady state assumption: its justification by singular perturbation theory and its application to the chemical master equation
• Quasi-steady state -- intuition, perturbation theory and algorithmic algebra
• Practical error analysis of the quasi-steady-state approximation
• Quasi-steady-state approximation for chemical reaction networks

zbMATH Keywords

error estimatesscalingquasi-steady-state assumptionMichaelis-Menten approximationfast transient

Mathematics Subject Classification ID

Singular perturbations for ordinary differential equations (34E15) Singular perturbations of ordinary differential equations (34D15) Physiological, cellular and medical topics (92Cxx)

Cited In (only showing first 100 items - show all)

• Singular perturbations and scaling
• On the anti-quasi-steady-state conditions of enzyme kinetics
• A kinetic analysis of coupled (or auxiliary) enzyme reactions
• The Status of the QSSA Approximation in Stochastic Simulations of Reaction Networks
• From enzyme kinetics to epidemiological models with Michaelis-Menten contact rate: design of nonstandard finite difference schemes
• Some nonstandard modeling techniques in theoretical biology
• Asymptotics of conduction velocity restitution in models of electrical excitation in the heart
• Approximation and inference methods for stochastic biochemical kinetics -- a tutorial review
• Efficacy of quasi-steady-state approximation in Michaelis-Menten kinetics: a stochastic signature
• Operating regimes of covalent modification cycles at high enzyme concentrations
• Modeling the action of drugs on cellular enzymes by means of optimal control techniques
• Single-substrate enzyme kinetics: the quasi-steady-state approximation and beyond
• Effects of periodic input on the quasi-steady state assumptions for enzyme-catalysed reactions
• Limits of noise for autoregulated gene expression
• Mathematical modelling of metapopulation dynamics: revisiting its meaning
• Critical parameters for singular perturbation reductions of chemical reaction networks
• Thresholds for disease persistence in models for tick-borne infections including non-viraemic transmission, extended feeding and tick aggregation
• Multi-timescale systems and fast-slow analysis
• On the validity and errors of the pseudo-first-order kinetics in ligand-receptor binding
• Slow-scale tau-leaping method
• Algorithmic reduction of biological networks with multiple time scales
• Classical quasi-steady state reduction -- a mathematical characterization
• A coordinate-independent version of Hoppensteadt's convergence theorem
• An alternative approach to Michaelis-Menten kinetics that is based on the renormalization group
• Approaches for the estimation of timescales in nonlinear dynamical systems: timescale separation in enzyme kinetics as a case study
• Quasi-steady state reduction for the Michaelis-Menten reaction-diffusion system
• Extension and justification of quasi-steady-state approximation for reversible bimolecular binding
• Quasi-steady-state and singular perturbation reduction for reaction networks with noninteracting species
• Trend to equilibrium for a reaction-diffusion system modelling reversible enzyme reaction
• General mathematical formula for near equilibrium relaxation kinetics of basic enzyme reactions and its applications to find conformational selection steps
• Qualitative dynamics of chemical reaction networks: an investigation using partial tropical equilibrations
• On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism
• Krylov and steady-state techniques for the solution of the chemical master equation for the mitogen-activated protein kinase cascade
• Theory on the rate equation of Michaelis-Menten type single-substrate enzyme catalyzed reactions
• Practical error analysis of the quasi-steady-state approximation
• A two-phase epidemic driven by diffusion
• Chattering as a singular problem
• Perturbation theory in the catalytic rate constant of the Henri-Michaelis-Menten enzymatic reaction
• New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper
• Reverse engineering: A model for T-cell vaccination
• The dynamics of simultaneous infections with altered susceptibilities
• Dynamical biocontrol systems: insights through mechanistic modelling
• Mechanisms controlling the sensitivity of amperometric biosensors in flow injection analysis systems
• Quasi-steady-state approximations derived from the stochastic model of enzyme kinetics
• Computational modelling of amperometric biosensors in the case of substrate and product inhibition
• The shuddering pendulum
• Deterministic and stochastic models of enzymatic networks-applications to pharmaceutical research
• On the simple Michaelis-Menten mechanism for chemical reactions
• Validity of the pseudo-steady-state approximation
• Algorithmic criteria for the validity of quasi-steady state and partial equilibrium models: the Michaelis-Menten reaction mechanism
• Computational efficiency and approximate inertial manifolds for a Bénard convection system
• Modeling inoculum dose dependent patterns of acute virus infections
• Chaos in a bienzymatic cyclic model with two autocatalytic loops
• Phase-plane geometries in coupled enzyme assays
• MOLECULAR REPLICATOR DYNAMICS
• Quasi-steady-state laws in reversible model of enzyme kinetics
• Enzyme kinetics far from the standard quasi-steady-state and equilibrium approximations
• Data-driven non-Markovian closure models
• On the validity of the steady state assumption of enzyme kinetics
• Reduction of a kinetic model of active export of importins
• A simplified perturbation solution of Michaelis-Menten kinetics equations in a ``total framework
• A theoretical and experimental study of competition between solution and surface receptors for ligand in a Biacore flow cell
• Asymptotic methods for reaction-diffusion systems: past and present
• The QSSA in chemical kinetics: as taught and as practiced
• Outbreak analysis of an SIS epidemic model with rewiring
• The Michaelis-Menten-Stueckelberg theorem
• Time dependent solution for acceleration of tau-leaping
• Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios
• Enzyme kinetics of multiple alternative substrates
• Bandwidth sharing networks with multiscale traffic
• The \(G\)-scheme: a framework for multi-scale adaptive model reduction
• Reversible-equivalent-monomolecular tau: a leaping method for ``small number and stiff stochastic chemical systems
• Extinction threshold for spatial forest dynamics with height structure
• On the Lambert \(w\) function
• A study case for the analysis of asymptotic expansions beyond the tQSSA for inhibitory mechanisms in enzyme kinetics.
• Challenges in pharmacology modelling
• A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentation
• An improved method to measure all rate constants in the simplest enzyme kinetics model
• Tikhonov's theorem and quasi-steady state
• Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?
• Scaling in biochemical kinetics: Dissection of a relaxation oscillator
• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Plant-pollinator population dynamics
• Multiscale stochastic simulation algorithm with stochastic partial equilibrium assumption for chemically reacting systems
• A novel approach to measure all rate constants in the simplest enzyme kinetics model
• Computational singular perturbation analysis of stochastic chemical systems with stiffness
• Effects of quasi-steady-state reduction on biophysical models with oscillations
• The steady-state assumption in oscillating and growing systems
• Error propagation in approximations to reaction-diffusion-advection equations.
• Quasi steady state and partial equilibrium approximations: their relation and their validity
• The total quasi-steady-state approximation is valid for reversible enzyme kinetics
• Asymptotic analysis of two reduction methods for systems of chemical reactions
• Extending the quasi-steady state approximation by changing variables
• A note on the kinetics of suicide substrates
• Computing quasi-steady state reductions
• The total quasi-steady-state approximation for complex enzyme reactions
• A constructive approach to quasi-steady state reductions
• Effective rate models for the analysis of transport-dependent biosensor data
• Individually-based Markov processes modeling nonlinear systems in mathematical biology
• Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution

This page was built for publication: The Quasi-Steady-State Assumption: A Case Study in Perturbation

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4728679)