Uniform approximation of solutions by elimination of intermediate species in deterministic reaction networks

DOI10.1137/16M109260XzbMATH Open1381.37105DBLPjournals/siamads/CappellettiW17arXiv1609.01405WikidataQ64004729 ScholiaQ64004729MaRDI QIDQ4601209FDOQ4601209

Authors: Daniele Cappelletti, Carsten Wiuf 

Publication date: 12 January 2018

Published in: SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Abstract: Chemical reactions often proceed through the formation and the consumption of intermediate species. An example is the creation and subsequent degradation of the substrate-enzyme complexes in an enzymatic reaction. In this paper we provide a setting, based on ordinary differential equations, in which the presence of intermediate species has little effect on the overall dynamics of a biological system. The result provides a method to perform model reduction by elimination of intermediate species. We study the problem in a multiscale setting, where the species abundances as well a the reaction rates scale to different orders of magnitudes. The different time and concentration scales are parameterised by a single parameter $N$. We show that a solution to the original reaction system is uniformly approximated on compact time intervals to a solution of a reduced reaction system without intermediates and to a solution of a certain limiting reaction systems, which does not depend on $N$. Known approximation techniques such as the theorems by Tikhonov and Fenichel cannot readily be used in this framework.

Full work available at URL: https://arxiv.org/abs/1609.01405

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zbMATH Keywords

mathematical biologyreaction networktrajectory approximation

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Theoretical approximation of solutions to ordinary differential equations (34A45) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Multiple scale methods for ordinary differential equations (34E13)

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Cited In (13)

• Stochastically modeled weakly reversible reaction networks with a single linkage class
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• Graphically balanced equilibria and stationary measures of reaction networks
• Oscillations and bistability in a model of ERK regulation
• Discrepancies between extinction events and boundary equilibria in reaction networks
• Coordinate-independent singular perturbation reduction for systems with three time scales
• On fast-slow consensus networks with a dynamic weight
• Elimination of the intermediate colloidal product in models of periodic precipitation patterns
• Elimination of intermediate species in multiscale stochastic reaction networks
• Graphical reduction of reaction networks by linear elimination of species
• Intermediates and generic convergence to equilibria
• Ergodicity analysis and antithetic integral control of a class of stochastic reaction networks with delays
• Normalizing chemical reaction networks by confluent structural simplification

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