Uniform approximation of solutions by elimination of intermediate species in deterministic reaction networks

DOI10.1137/16M109260XMaRDI QIDQ4601209zbMATH OpenDBLPWikidataFDO

Authors Daniele Cappelletti, Carsten Wiuf

Publication date 12 January 2018

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1609.01405

zbMATH Keywords

mathematical biologyreaction networktrajectory approximation

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Theoretical approximation of solutions to ordinary differential equations (34A45) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Multiple scale methods for ordinary differential equations (34E13)

Abstract: Chemical reactions often proceed through the formation and the consumption of intermediate species. An example is the creation and subsequent degradation of the substrate-enzyme complexes in an enzymatic reaction. In this paper we provide a setting, based on ordinary differential equations, in which the presence of intermediate species has little effect on the overall dynamics of a biological system. The result provides a method to perform model reduction by elimination of intermediate species. We study the problem in a multiscale setting, where the species abundances as well a the reaction rates scale to different orders of magnitudes. The different time and concentration scales are parameterised by a single parameter $N$. We show that a solution to the original reaction system is uniformly approximated on compact time intervals to a solution of a reduced reaction system without intermediates and to a solution of a certain limiting reaction systems, which does not depend on $N$. Known approximation techniques such as the theorems by Tikhonov and Fenichel cannot readily be used in this framework.

Recommendations

• Elimination of intermediate species in multiscale stochastic reaction networks
• Graphical reduction of reaction networks by linear elimination of species
• Model reduction of chemical reaction systems using elimination
• Fast reactions with non-interacting species in stochastic reaction networks
• Intermediates and generic convergence to equilibria

Cites work

• scientific article; zbMATH DE number 44637 (Why is no real title available?)
• scientific article; zbMATH DE number 734901 (Why is no real title available?)
• scientific article; zbMATH DE number 1462120 (Why is no real title available?)
• scientific article; zbMATH DE number 3047763 (Why is no real title available?)
• scientific article; zbMATH DE number 3075094 (Why is no real title available?)
• A constructive approach to quasi-steady state reductions
• Delay differential equations: with applications in population dynamics
• Elimination of intermediate species in multiscale stochastic reaction networks
• Geometric singular perturbation theory for ordinary differential equations
• Intermediates, catalysts, persistence, and boundary steady states
• Power-law kinetics and determinant criteria for the preclusion of multistationarity in networks of interacting species
• Quasi-steady-state approximation in the mathematical modeling of biochemical reaction networks
• Scaling limits of spatial compartment models for chemical reaction networks
• The Quasi-Steady-State Assumption: A Case Study in Perturbation

Cited in

(13)

• Stochastically modeled weakly reversible reaction networks with a single linkage class
• Tier structure of strongly endotactic reaction networks
• Graphically balanced equilibria and stationary measures of reaction networks
• Oscillations and bistability in a model of ERK regulation
• Discrepancies between extinction events and boundary equilibria in reaction networks
• Coordinate-independent singular perturbation reduction for systems with three time scales
• On fast-slow consensus networks with a dynamic weight
• Elimination of the intermediate colloidal product in models of periodic precipitation patterns
• Elimination of intermediate species in multiscale stochastic reaction networks
• Graphical reduction of reaction networks by linear elimination of species
• Intermediates and generic convergence to equilibria
• Ergodicity analysis and antithetic integral control of a class of stochastic reaction networks with delays
• Normalizing chemical reaction networks by confluent structural simplification

This page was built for publication: Uniform approximation of solutions by elimination of intermediate species in deterministic reaction networks

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4601209)