Modeling the action of drugs on cellular enzymes by means of optimal control techniques
DOI10.1007/S10910-010-9775-2zbMATH Open1217.34077OpenAlexW2053964433MaRDI QIDQ551833FDOQ551833
Authors: Alberto Bersani, Enrico Bersani, Loretta Mastroeni 
Publication date: 21 July 2011
Published in: Journal of Mathematical Chemistry (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1007/s10910-010-9775-2
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Hamilton-Jacobi equationsMichaelis-Menten kineticsviscosity solutionsdrug discoveryintracellular signal transduction
Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60) Systems biology, networks (92C42) Dynamic programming in optimal control and differential games (49L20)
Cites Work
- Viscosity solutions of Hamilton-Jacobi equations
- Michaelis-Menten kinetics at high enzyme concentrations
- Optimal control and viscosity solutions of Hamilton-Jacobi-Bellman equations
- Extending the quasi-steady state approximation by changing variables
- The Quasi-Steady-State Assumption: A Case Study in Perturbation
- Title not available (Why is that?)
- Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution
- The total quasi-steady-state approximation for complex enzyme reactions
- Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity
- The total quasi-steady-state approximation for fully competitive enzyme reactions
- Optimal control of self-organized dynamics in cellular signal transduction
- EXPLOITING OPTIMAL CONTROL FOR TARGET-ORIENTED MANIPULATION OF (BIO)CHEMICAL SYSTEMS: A MODEL-BASED APPROACH TO SPECIFIC MODIFICATION OF SELF-ORGANIZED DYNAMICS
Cited In (6)
- Optimal control of self-organized dynamics in cellular signal transduction
- Optimal control study on Michaelis-Menten kinetics -- a fractional version
- Application of optimal control techniques and advanced computing to the study of enzyme kinetics
- Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement
- Computing optimal properties of drugs using mathematical models of single channel dynamics
- New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper
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