Modeling the action of drugs on cellular enzymes by means of optimal control techniques

DOI10.1007/S10910-010-9775-2MaRDI QIDQ551833zbMATH OpenOpenAlexFDO

Authors Alberto Bersani, Enrico Bersani, Loretta Mastroeni

Publication date 21 July 2011

Published in Journal of Mathematical Chemistry (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s10910-010-9775-2

zbMATH Keywords

Hamilton-Jacobi equationsMichaelis-Menten kineticsviscosity solutionsdrug discoveryintracellular signal transduction

Mathematics Subject Classification ID

Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60) Systems biology, networks (92C42) Dynamic programming in optimal control and differential games (49L20)

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Cites work

• scientific article; zbMATH DE number 819507 (Why is no real title available?)
• EXPLOITING OPTIMAL CONTROL FOR TARGET-ORIENTED MANIPULATION OF (BIO)CHEMICAL SYSTEMS: A MODEL-BASED APPROACH TO SPECIFIC MODIFICATION OF SELF-ORGANIZED DYNAMICS
• Extending the quasi-steady state approximation by changing variables
• Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity
• Michaelis-Menten kinetics at high enzyme concentrations
• Optimal control and viscosity solutions of Hamilton-Jacobi-Bellman equations
• Optimal control of self-organized dynamics in cellular signal transduction
• Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• The total quasi-steady-state approximation for complex enzyme reactions
• The total quasi-steady-state approximation for fully competitive enzyme reactions
• Viscosity solutions of Hamilton-Jacobi equations

Cited in

(6)

• Optimal control of self-organized dynamics in cellular signal transduction
• Optimal control study on Michaelis-Menten kinetics -- a fractional version
• Application of optimal control techniques and advanced computing to the study of enzyme kinetics
• Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement
• Computing optimal properties of drugs using mathematical models of single channel dynamics
• New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper

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