Computing optimal properties of drugs using mathematical models of single channel dynamics
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Cites work
- A note on a method for determining advantageous properties of an anti-arrhythmic drug based on a mathematical model of cardiac cells
- A population density approach that facilitates large-scale modeling of neural networks: Analysis and an application in orientation tuning
- An operator splitting method for solving the bidomain equations coupled to a volume conductor model for the torso
- Computational cell biology
- Computing characterizations of drugs for ion channels and receptors using Markov models
- Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states
- Defining candidate drug characteristics for Long-QT (LQT3) syndrome
- Elements of scientific computing
- Finite Volume Methods for Hyperbolic Problems
- HOW ANTIARRHYTHMIC DRUGS INCREASE THE RATE OF SUDDEN CARDIAC DEATH
- scientific article; zbMATH DE number 720688 (Why is no real title available?)
- scientific article; zbMATH DE number 1796810 (Why is no real title available?)
- Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors
- Mathematical physiology. I: Cellular physiology
- MCMC for hidden Markov models incorporating aggregation of states and filtering
- Non-spatial whole cell models of global calcium responses that account for heterogeneous domain calcium concentrations
- On the accuracy of operator splitting for the monodomain model of electrophysiology
- Stochastic processes in cell biology
- The dynamics of luminal depletion and the stochastic gating of \(\operatorname{Ca}^{2 +} \)-activated \(\operatorname{Ca}^{2 +}\) channels and release sites
- The effect of residual \(\operatorname{Ca}^{2 +}\) on the stochastic gating of \(\operatorname{Ca}^{2 +} \)-regulated \(\operatorname{Ca}^{2 +}\) channel models
Cited in
(4)- Combination of multi-variable quadratic adaptive algorithm and hybrid operator splitting method for stability against acceleration in the Markov model of sodium ion channels in the ventricular cell model
- On complex dynamics in a Purkinje and a ventricular cardiac cell model
- Computing characterizations of drugs for ion channels and receptors using Markov models
- Bifurcation analysis of a modified cardiac cell model
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