Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?

DOI10.1007/s10910-010-9770-7zbMath1366.92055MaRDI QIDQ431971

Guido Dell'Acqua, Alberto Maria Bersani

Publication date: 3 July 2012

Published in: Journal of Mathematical Chemistry (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10910-010-9770-7

zbMATH Keywords

asymptotic expansions; Michaelis-Menten kinetics; quasi-steady state approximations

Mathematics Subject Classification ID

92C45: Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.)

34C60: Qualitative investigation and simulation of ordinary differential equation models

Related Items

Uniform Asymptotic Expansions beyond the tQSSA for the Goldbeter--Koshland Switch, The unreasonable effectiveness of the total quasi-steady state approximation, and its limitations, On the Hausdorff distance between the Heaviside step function and Verhulst logistic function, Metabolic rate constants: some computational aspects, On a stochastic approach to model the double phosphorylation/dephosphorylation cycle, Characteristic, completion or matching timescales? An analysis of temporary boundaries in enzyme kinetics, General mathematical formula for near equilibrium relaxation kinetics of basic enzyme reactions and its applications to find conformational selection steps, Single-substrate enzyme kinetics: the quasi-steady-state approximation and beyond, New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper

Cites Work

• Michaelis-Menten kinetics at high enzyme concentrations
• Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution
• The total quasi-steady-state approximation for complex enzyme reactions
• On the validity of the steady state assumption of enzyme kinetics
• Extending the quasi-steady state approximation by changing variables
• Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity
• The total quasi-steady-state approximation for fully competitive enzyme reactions
• Properties of the Michaelis-Menten mechanism in phase space
• Quasi-steady state in the Michaelis-Menten system
• Multiscale Modeling of Chemical Kinetics via the Master Equation
• The Quasi-Steady-State Assumption: A Case Study in Perturbation