Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?

DOI10.1007/s10910-010-9770-7zbMath1366.92055OpenAlexW2083017692MaRDI QIDQ431971

Guido Dell'Acqua, Alberto Maria Bersani

Publication date: 3 July 2012

Published in: Journal of Mathematical Chemistry (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10910-010-9770-7

zbMATH Keywords

asymptotic expansionsMichaelis-Menten kineticsquasi-steady state approximations

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Qualitative investigation and simulation of ordinary differential equation models (34C60)

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Cites Work

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• Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution
• The total quasi-steady-state approximation for complex enzyme reactions
• On the validity of the steady state assumption of enzyme kinetics
• Extending the quasi-steady state approximation by changing variables
• Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity
• The total quasi-steady-state approximation for fully competitive enzyme reactions
• Properties of the Michaelis-Menten mechanism in phase space
• Quasi-steady state in the Michaelis-Menten system
• Multiscale Modeling of Chemical Kinetics via the Master Equation
• The Quasi-Steady-State Assumption: A Case Study in Perturbation