Properties of the Michaelis-Menten mechanism in phase space

DOI10.1016/J.JMAA.2007.06.078zbMATH Open1126.92018arXivmath/0611119OpenAlexW2074707866MaRDI QIDQ2465865FDOQ2465865

Authors: Matt S. Calder, David Siegel 

Publication date: 10 January 2008

Published in: Journal of Mathematical Analysis and Applications (Search for Journal in Brave)

Abstract: We study the two-dimensional reduction of the Michaelis-Menten reaction of enzyme kinetics. First, we prove the existence and uniqueness of a slow manifold between the horizontal and vertical isoclines. Second, we determine the concavity of all solutions in the first quadrant. Third, we establish the asymptotic behaviour of all solutions near the origin, which generally is not given by a Taylor series. Finally, we determine the asymptotic behaviour of the slow manifold at infinity.

Full work available at URL: https://arxiv.org/abs/math/0611119

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zbMATH Keywords

asymptoticsenzymecentre manifoldslow manifold

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Dynamical systems in biology (37N25) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Applications of centre manifold theory
• Singular perturbation methods for ordinary differential equations
• Mathematical biology. Vol. 1: An introduction.
• Title not available (Why is that?)
• Title not available (Why is that?)
• Mathematical physiology
• Title not available (Why is that?)
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• Title not available (Why is that?)
• Asymptotic analysis of two reduction methods for systems of chemical reactions
• Title not available (Why is that?)
• Projecting to a Slow Manifold: Singularly Perturbed Systems and Legacy Codes
• Invariant manifold methods for metabolic model reduction
• Forced-convergence iterative schemes for the approximation of invariant manifolds
• On the simple Michaelis-Menten mechanism for chemical reactions

Cited In (13)

• Title not available (Why is that?)
• On the anti-quasi-steady-state conditions of enzyme kinetics
• Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?
• Properties of the lindemann mechanism in phase space
• Reduction for Michaelis-Menten-Henri kinetics in the presence of diffusion
• Some mathematical properties of the Lindemann mechanism
• Heineken, Tsuchiya and Aris: ``On the mathematical status of the pseudo-steady state hypothesis. A classic from Volume 1 of \textit{Mathematical Biosciences}
• Dynamics of the modified Michaelis--Menten system
• Extension and justification of quasi-steady-state approximation for reversible bimolecular binding
• On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism
• Michaelis-Menten equation for degradation of insoluble substrate
• Phase-plane geometries in coupled enzyme assays
• Rigorous estimates for the quasi-steady state approximation of the Michaelis-Menten reaction mechanism at low enzyme concentrations

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