Quasi steady-state approximations in complex intracellular signal transduction networks - a word of caution

DOI10.1007/S10910-007-9248-4zbMATH Open1217.92052OpenAlexW2027571621MaRDI QIDQ551897FDOQ551897

Authors: Morten Gram Pedersen, Alberto Bersani, Enrico Bersani 

Publication date: 21 July 2011

Published in: Journal of Mathematical Chemistry (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10910-007-9248-4

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zbMATH Keywords

Michaelis-Menten kineticsdouble phosphorylationenzyme signaling networksMAPK cascadequasi steady-state assumption

Mathematics Subject Classification ID

Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Michaelis-Menten kinetics at high enzyme concentrations
• Extending the quasi-steady state approximation by changing variables
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• Time-dependent closed form solutions for fully competitive enzyme reactions
• Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios

Cited In (24)

• Singular perturbation techniques and asymptotic expansions for some complex enzyme reactions
• A study case for the analysis of asymptotic expansions beyond the tQSSA for inhibitory mechanisms in enzyme kinetics.
• Modeling the action of drugs on cellular enzymes by means of optimal control techniques
• Long-term behaviours of autocatalytic sets
• Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?
• Uniform asymptotic expansions beyond the tQSSA for the Goldbeter-Koshland switch
• Effects of quasi-steady-state reduction on biophysical models with oscillations
• Quasi steady state and partial equilibrium approximations: their relation and their validity
• The total quasi-steady-state approximation for complex enzyme reactions
• Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
• Reduced models of networks of coupled enzymatic reactions
• Approximations and their consequences for dynamic modelling of signal transduction pathways
• Approximation of enzyme kinetics for high enzyme concentration by a first order perturbation approach
• Partial equilibrium approximations in apoptosis. I: The intracellular-signaling subsystem
• New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper
• A perturbation solution of Michaelis-Menten kinetics in a ``total framework
• On the qualitative behaviour of oscillating biochemical systems: the stochastic approach
• Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity
• The total quasi-steady-state approximation for fully competitive enzyme reactions
• No-oscillation theorem for the transient dynamics of the linear signal transduction pathway and beyond
• Deterministic and stochastic models of enzymatic networks-applications to pharmaceutical research
• A new Michaelis-Menten equation valid everywhere multi-scale dynamics prevails
• Algorithmic criteria for the validity of quasi-steady state and partial equilibrium models: the Michaelis-Menten reaction mechanism
• Balanced truncation for model reduction of biological oscillators

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