The unreasonable effectiveness of the total quasi-steady state approximation, and its limitations

DOI10.1016/j.jtbi.2024.111770MaRDI QIDQ6130760

Sebastian Walcher, Santiago Schnell, Justin S. Eilertsen

Publication date: 3 April 2024

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

zbMATH Keywords

singular perturbationeigenvaluesvalidityquasi-steady-state approximationtimescalesMichaelis-Menten reaction

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Unnamed Item
• Unnamed Item
• Michaelis-Menten kinetics at high enzyme concentrations
• Is there anything left to say on enzyme kinetic constants and quasi-steady state approximation?
• A constructive approach to quasi-steady state reductions
• Tikhonov's theorem and quasi-steady state
• Geometric singular perturbation theory for ordinary differential equations
• Enzyme kinetics far from the standard quasi-steady-state and equilibrium approximations
• Classical quasi-steady state reduction -- a mathematical characterization
• Extending the quasi-steady state approximation by changing variables
• On the anti-quasi-steady-state conditions of enzyme kinetics
• Determining ``small parameters for quasi-steady state
• On the Structure of Local Homeomorphisms of Euclidean n-Space, II
• The unreasonable effectiveness of mathematics in the natural sciences. Richard courant lecture in mathematical sciences delivered at New York University, May 11, 1959
• The Quasi-Steady-State Assumption: A Case Study in Perturbation