A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback

DOI10.1007/S00285-013-0675-5MaRDI QIDQ2447559zbMATH OpenOpenAlexWikidataFDO

Authors Gianne Derks, Balaji M. Agoram, Piet H. van der Graaf, Philip J. Aston

Publication date 28 April 2014

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-013-0675-5

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Dynamical systems in biology (37N25) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites work

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• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Geometric singular perturbation theory for ordinary differential equations
• scientific article; zbMATH DE number 758785 (Why is no real title available?)
• scientific article; zbMATH DE number 5199276 (Why is no real title available?)
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency

Cited in

(7)

• Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC
• A mathematical analysis of rebound in a target-mediated drug disposition model. II. With feedback
• Impact of enzyme turnover on the dynamics of the Michaelis-Menten model
• Geometric singular perturbation analysis of a dynamical target mediated drug disposition model
• Topics in mathematical pharmacology
• Dynamics of a two-receptor binding model: how affinities and capacities translate into long and short time behaviour and physiological corollaries
• RECEPTOR-MEDIATED ENDOCYTOSIS MODELING OF ANTIBODY-DRUG CONJUGATES TO THE RELEASED PAYLOAD WITHIN THE INTRACELLULAR SPACE CONSIDERING TARGET ANTIGEN EXPRESSION LEVELS

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