IL-27 in combination with anti-PD-1 can be anti-cancer or pro-cancer

DOI10.1016/J.JTBI.2023.111704MaRDI QIDQ6177320zbMATH OpenOpenAlexFDO

Authors Kang-Ling Liao, Xue-Feng Bai, A. Friedman

Publication date 17 January 2024

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2023.111704

zbMATH Keywords

anti-PD-1combination therapyimmune checkpoint inhibitorsinterleukin-27

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Medical applications (general) (92C50)

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Cites work

• A mathematical model of tumor-immune interactions
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Mathematical model of sarcoidosis
• Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor
• Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour
• The role of exosomes in pancreatic cancer microenvironment

Cited in

(3)

• Modelling immune dynamics in locally advanced MSI-H/dMMR colorectal cancer with neoadjuvant pembrolizumab treatment: from differential equations to an agent-based framework
• Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations
• Optimisation of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations

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