Mathematical modeling for the combination treatment of IFN- and anti-PD-1 in cancer immunotherapy

DOI10.1016/J.MBS.2022.108911zbMATH Open1505.92103OpenAlexW4296769722MaRDI QIDQ2103601FDOQ2103601

Authors: Kang-Ling Liao, Kenton D. Watt 

Publication date: 9 December 2022

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2022.108911

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zbMATH Keywords

anti-PD-1combination immunotherapyIFN-\(\gamma\)immune checkpointPDEs model

Mathematics Subject Classification ID

Medical applications (general) (92C50) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Cites Work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Modeling the inhibition of breast cancer growth by GM-CSF
• Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour
• A mathematical model of tumor-immune interactions
• Title not available (Why is that?)
• The role of exosomes in pancreatic cancer microenvironment
• Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor

Cited In (17)

• Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor
• Mathematical modeling and analysis of CD200-CD200R in cancer treatment
• Dynamic analysis of a drug resistance evolution model with nonlinear immune response
• Mathematical modeling and analysis of cancer treatment with radiation and anti-PD-L1
• Mathematical modeling of tumor immune interactions: the role of anti-FGFR and anti-PD-1 in the combination therapy
• A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor
• Combination therapy for cancer with IL-27 and anti-PD-1: A simplified mathematical model
• A mechanistic systems pharmacology modeling platform to investigate the effect of PD-L1 expression heterogeneity and dynamics on the efficacy of PD-1 and PD-L1 blocking antibodies in cancer
• IL-27 in combination with anti-PD-1 can be anti-cancer or pro-cancer
• B7-H1 and a mathematical model for cytotoxic T cell and tumor cell interaction
• Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment
• Cancer therapy with immune checkpoint inhibitor and CSF-1 blockade: a mathematical model
• Modeling LSD1-mediated tumor stagnation
• Antagonism and negative side-effects in combination therapy for cancer
• Targeting CD4+ T cell exhaustion to improve future immunotherapy strategies
• Computational modeling and experimental investigations to enhance the successful response of anti-PD-\(1\) cancer immunotherapies
• THE EFFECT OF LENVATINIB AND PEMBROLIZUMAB ON THYROID CANCER REFRACTORY TO IODINE 131I SIMULATED BY MATHEMATICAL MODELING

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