Mathematical modeling of an immune checkpoint inhibitor and its synergy with an immunostimulant

DOI10.3934/DCDSB.2020138zbMATH Open1464.92132OpenAlexW3023942812MaRDI QIDQ2033441FDOQ2033441

Authors: Elpiniki Nikolopoulou, Steffen E. Eikenberry, Jana L. Gevertz, Yang Kuang 

Publication date: 17 June 2021

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/dcdsb.2020138

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zbMATH Keywords

mathematical modelsynergymathematical analysisPD-L1combination treatmentimmune checkpoint inhibitorsimmunostimulant

Mathematics Subject Classification ID

Medical applications (general) (92C50) Positive solutions to nonlinear boundary value problems for ordinary differential equations (34B18) Periodic solutions to PDEs (35B10)

Cites Work

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• A comparison and catalog of intrinsic tumor growth models
• Dynamics analysis of a predator-prey system with harvesting prey and disease in prey species
• Patient-specific parameter estimates of glioblastoma multiforme growth dynamics from a model with explicit birth and death rates

Cited In (37)

• Bifurcations of a cancer immunotherapy model explaining the transient delayed response and various other responses
• Cytokine storm mitigation for exogenous immune agonists
• A prognostic immunotherapy model for 4T1 breast cancer with combined cyclophosphamide and TLR agonist
• Response of patients with melanoma to immune checkpoint blockade -- insights gleaned from analysis of a new mathematical mechanistic model
• Mathematical modeling for the combination treatment of IFN-\(\gamma\) and anti-PD-1 in cancer immunotherapy
• Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor
• Global stability and parameter analysis reinforce therapeutic targets of PD-L1-PD-1 and MDSCs for glioblastoma
• In silico synergism and antagonism of an anti-tumour system intervened by coupling immunotherapy and chemotherapy: a mathematical modelling approach
• A feedback control model of comprehensive therapy for treating immunogenic tumours
• Investigating tumor-host response dynamics in preclinical immunotherapy experiments using a stepwise mathematical modeling strategy
• Mathematical modeling, analysis, and simulation of tumor dynamics with drug interventions
• Bifurcation Analysis in a Tumor-Immune System Interaction Model with Dendritic Cell Therapy and Immune Response Delay
• Mathematical modeling of tumor immune interactions: the role of anti-FGFR and anti-PD-1 in the combination therapy
• A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor
• Combination therapy for cancer with IL-27 and anti-PD-1: A simplified mathematical model
• Cancer therapy with immune checkpoint inhibitor and CSF-1 blockade: a mathematical model
• Modelling of killer T-cell and cancer cell subpopulation dynamics under immuno- and chemotherapies
• Dynamic analysis of a model on tumor-immune system with regulation of PD-1/PD-L1 and stimulation delay of tumor antigen
• Dynamics of immune checkpoints, immune system, and BCG in the treatment of superficial bladder cancer
• Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer
• A Delayed Dynamical Model Describing the Effect of Tumor-Induced Vascular Endothelial Growth Factor on Angiogenesis: Backward Bifurcations and Global Dynamics
• Treatment of melanoma with dendritic cell vaccines and immune checkpoint inhibitors: a mathematical modeling study
• Predicting resistance and pseudoprogression: are minimalistic immunoediting mathematical models capable of forecasting checkpoint inhibitor treatment outcomes in lung cancer?
• Computation of the conditions for anti-angiogenesis and gene therapy synergistic effects: sensitivity analysis and robustness of target solutions
• A mathematical model for cancer treatment based on combination of anti-angiogenic and immune cell therapies
• Modeling the effect of gut microbiome on therapeutic efficacy of immune checkpoint inhibitors against cancer
• Mathematical modelling of autoimmune myocarditis and the effects of immune checkpoint inhibitors
• Stability and Hopf bifurcation of a tumor-immune system interaction model with an immune checkpoint inhibitor
• A mathematical model of the enhancement of tumor vaccine efficacy by immunotherapy
• Developing a minimally structured mathematical model of cancer treatment with oncolytic viruses and dendritic cell injections
• Analysis of tumor-immune functional responses in a mathematical model of neoantigen cancer vaccines
• On modeling the synergy of cancer immunotherapy with radiotherapy
• Mathematical modeling and solution landscape reveal cancer progression dynamics in tumor ecological microenvironment
• Optimal control of combination immunotherapy for a virtual murine cohort in a glioblastoma-immune dynamics model
• PULSAR effect: revealing potential synergies in combined radiation therapy and immunotherapy via differential equations
• Use of quasi-normal form to examine stability of tumor-free equilibrium in a mathematical model of BCG treatment of bladder cancer
• Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy

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