Mathematical modeling of an immune checkpoint inhibitor and its synergy with an immunostimulant

DOI10.3934/DCDSB.2020138zbMATH Open1464.92132OpenAlexW3023942812MaRDI QIDQ2033441FDOQ2033441

Authors: Elpiniki Nikolopoulou, Steffen E. Eikenberry, Jana L. Gevertz, Yang Kuang

Publication date: 17 June 2021

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/dcdsb.2020138

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zbMATH Keywords

mathematical model synergy mathematical analysis PD-L1 combination treatment immune checkpoint inhibitors immunostimulant

Mathematics Subject Classification ID

Medical applications (general) (92C50) Positive solutions to nonlinear boundary value problems for ordinary differential equations (34B18) Periodic solutions to PDEs (35B10)

Cites Work

Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
A trust region method based on interior point techniques for nonlinear programming.
Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections
Estimating tumor growth rates in vivo
A comparison and catalog of intrinsic tumor growth models
Dynamics analysis of a predator–prey system with harvesting prey and disease in prey species
Patient-specific parameter estimates of glioblastoma multiforme growth dynamics from a model with explicit birth and death rates

Cited In (18)

Bifurcations of a cancer immunotherapy model explaining the transient delayed response and various other responses
Mathematical modeling for the combination treatment of IFN-\(\gamma\) and anti-PD-1 in cancer immunotherapy
Global stability and parameter analysis reinforce therapeutic targets of PD-L1-PD-1 and MDSCs for glioblastoma
In silico synergism and antagonism of an anti-tumour system intervened by coupling immunotherapy and chemotherapy: a mathematical modelling approach
Bifurcation Analysis in a Tumor-Immune System Interaction Model with Dendritic Cell Therapy and Immune Response Delay
Combination therapy for cancer with IL-27 and anti-PD-1: A simplified mathematical model
Cancer therapy with immune checkpoint inhibitor and CSF-1 blockade: a mathematical model
Dynamic analysis of a model on tumor-immune system with regulation of PD-1/PD-L1 and stimulation delay of tumor antigen
A Delayed Dynamical Model Describing the Effect of Tumor-Induced Vascular Endothelial Growth Factor on Angiogenesis: Backward Bifurcations and Global Dynamics
Treatment of melanoma with dendritic cell vaccines and immune checkpoint inhibitors: a mathematical modeling study
A mathematical model for cancer treatment based on combination of anti-angiogenic and immune cell therapies
Modeling the effect of gut microbiome on therapeutic efficacy of immune checkpoint inhibitors against cancer
Stability and Hopf bifurcation of a tumor-immune system interaction model with an immune checkpoint inhibitor
A mathematical model of the enhancement of tumor vaccine efficacy by immunotherapy
Analysis of tumor-immune functional responses in a mathematical model of neoantigen cancer vaccines
On modeling the synergy of cancer immunotherapy with radiotherapy
Mathematical modeling and solution landscape reveal cancer progression dynamics in tumor ecological microenvironment
Use of quasi-normal form to examine stability of tumor-free equilibrium in a mathematical model of BCG treatment of bladder cancer

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