Modeling the effect of gut microbiome on therapeutic efficacy of immune checkpoint inhibitors against cancer

DOI10.1016/J.MBS.2022.108868MaRDI QIDQ2164665zbMATH OpenOpenAlexFDO

Authors Yanyan Li

Publication date 15 August 2022

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2022.108868

zbMATH Keywords

mathematical modelingpredictive biomarkersimmune checkpoint inhibitorsgut bacteriaanti-tumor efficacy

Mathematics Subject Classification ID

Medical applications (general) (92C50) Microbiology (92C70)

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Cites work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• An extended mathematical model of tumor growth and its interaction with the immune system, to be used for developing an optimized immunotherapy treatment protocol
• Mathematical modeling of an immune checkpoint inhibitor and its synergy with an immunostimulant

Cited in

(5)

• LRBmat: a novel gut microbial interaction and individual heterogeneity inference method for colorectal cancer
• Mathematical modeling of tumor immune interactions: the role of anti-FGFR and anti-PD-1 in the combination therapy
• A mechanistic systems pharmacology modeling platform to investigate the effect of PD-L1 expression heterogeneity and dynamics on the efficacy of PD-1 and PD-L1 blocking antibodies in cancer
• Optimal control of tumor-lymphatic model with immuno-chemotherapy
• Modeling tumour heterogeneity of PD-L1 expression in tumour progression and adaptive therapy

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