Response of patients with melanoma to immune checkpoint blockade -- insights gleaned from analysis of a new mathematical mechanistic model

DOI10.1016/j.jtbi.2019.110033zbMath1425.92120OpenAlexW2978385326WikidataQ90456096 ScholiaQ90456096MaRDI QIDQ2335370

N. Tsur, M. Rehm, Yuri Kogan, Zvia Agur

Publication date: 14 November 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2019.110033

zbMATH Keywords

simulationHopf bifurcationphase-plane analysiscancer immunotherapypembrolizumab

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) Medical applications (general) (92C50)

Related Items (6)

Co-dimension two bifurcations analysis of a delayed tumor model with Allee effect ⋮ Dynamical Analysis of a Melanoma Model with Immune Response ⋮ A tumor-Immune interaction model with the effect of impulse therapy ⋮ Stability and Hopf bifurcation of a tumor-immune system interaction model with an immune checkpoint inhibitor ⋮ Treatment of melanoma with dendritic cell vaccines and immune checkpoint inhibitors: a mathematical modeling study ⋮ Stability and Hopf bifurcations in a competitive tumour-immune system with intrinsic recruitment delay and chemotherapy

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