Modeling within-host viral dynamics: the role of CTL immune responses in the evolution of drug resistance

DOI10.3934/DCDSB.2020245MaRDI QIDQ2033746zbMATH OpenOpenAlexFDO

Authors Qi Deng, Zhipeng Qiu, Ting Guo, Libin Rong

Publication date 17 June 2021

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/dcdsb.2020245

zbMATH Keywords

sensitivity analysisstabilityantiretroviral therapydrug resistanceCTL immune response

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) Pathology, pathophysiology (92C32)

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Cites work

• A delay-dependent model with HIV drug resistance during therapy
• A mathematical model for the emergence of HIV drug resistance during periodic bang-bang type antiretroviral treatment
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
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• Analysis of an HIV model with immune responses and cell-to-cell transmission
• Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
• Complex dynamic behavior in a viral model with delayed immune response
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• Emergence of HIV-1 drug resistance during antiretroviral treatment
• Estimating kinetic parameters from HIV primary infection data through the eyes of three different mathematical models
• Global properties of a delayed HIV infection model with CTL immune response
• Global stability for a class of virus models with cytotoxic T Lymphocyte immune response and antigenic variation
• Global stability in a viral infection model with lytic and nonlytic immune responses
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• Mathematical modeling of HIV-1 infection and drug therapy
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• Optimal HIV treatment by maximising immune response
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Cited in

(14)

• A mathematical model for HIV dynamics with multiple infections: implications for immune escape
• Modeling the effect of reactive oxygen species and CTL immune response on HIV dynamics
• Drug resistance in acute viral infections: rhinovirus as a case study
• Escaping stochastic extinction of mutant virus: temporal pattern of emergence of drug resistance within a host
• Dynamic analysis of a drug resistance evolution model with nonlinear immune response
• A mathematical model for CTL effect on drug resistence during antiretroviral treatment of HIV infection
• Modeling the effects of drugs of abuse on within-host dynamics of two HIV species
• Sampling HIV intrahost genealogies based on a model of acute stage CTL response
• Dynamics of an HIV infection model with two infection routes and evolutionary competition between two viral strains
• Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility
• A within-host drug resistance model with continuous state-dependent viral strains
• Towards a new combination therapy with vectored immunoprophylaxis for HIV: modeling ``Shock and kill strategy
• Bifurcation analysis and chaos for a double-strains HIV coinfection model with intracellular delays, saturated incidence and logistic growth
• Modeling the effect of activation of CD\(4^+\) T cells on HIV dynamics

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